Item Details

Protocols to Improve the Electrophysiological Maturity of iPSC-Derived Neurons

Harbom, Lise
Format
Thesis/Dissertation; Online
Author
Harbom, Lise
Advisor
Beenhakker, Mark
McConnell, Michael
Abstract
Achieving functional maturity in iPSC-derived neurons is an ongoing goal in the field. In order to achieve this goal, it is likely necessary to evaluate the human development of electrical activity in vivo and the factors that affect the successful wiring of neural networks. The work presented in this dissertation seeks to evaluate how altering a few of these factors via culture conditions during neuronal maturation contributes to long-term electrophysiological maturity.
Language
English
Published
University of Virginia, Department of Neuroscience, PHD (Doctor of Philosophy), 2019
Published Date
2019-05-05
Degree
PHD (Doctor of Philosophy)
Collection
Libra ETD Repository
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