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The Biology of the TGF-[Beta Family]

edited by Rik Derynck, University of California, San Francisco and Kohei Miyazono, University of Tokyo
Format
Book
Published
Cold Spring Harbor, New York : Cold Spring Harbor Laboratory Press, [2016]
Language
English
ISBN
9781621820369 (hardback)
Summary
" Members of the transforming growth factor b (TGFb) family, which include activins and bone morphogenetic proteins (BMPs), are essential intercellular signaling molecules that control of cell proliferation and embryonic development. This books provides a comprehensive view of the different members of the TGFb family and their receptors, as well as their roles in normal physiology and development and pathological conditions such as cancer. "--
"Members of the transforming growth factor β (TGFβ) family, which include activins and bone morphogenetic proteins (BMPs), are essential intercellular signaling molecules that control of cell proliferation and embryonic development. This book provides a comprehensive view of the different members of the TGFβ family and their receptors, as well as their roles in normal physiology and development and pathological conditions such as cancer"--
Contents
  • Machine generated contents note
  • (preliminary)
  • 1. The discovery and early days of TGF-Beta: a historical perspective.
  • Hal Moses, Anita Roberts, Rik Derynck
  • 2. TGF-Beta and the TGF-Beta family, context-dependent roles in cell and tissue physiology
  • Kohei Miyazono, Rik Derynck
  • 3. Activins and inhibins
  • Chester Brown
  • 4. Bone morphogenetic proteins
  • Takenobu Katagiri, Tetsu Watabe
  • 5. Regulation of the bioavailability of TGF-Beta and TGF-Beta-related proteins
  • Dan Rifkin
  • 6. Agonists and antagonists of TGF-Beta family ligands
  • Chenbei Chang
  • 7. TGF-Beta family receptors
  • Calle Heldin and Aris Moustakas
  • 8. TGF-Beta signaling from receptors to Smads
  • Akiko Hata, Ye-Guang Chen
  • 9. Transcriptional control by Smads
  • Caroline Hill
  • 10. Post-translational control of Smads
  • Xin-Hua Feng
  • 11. Regulation of TGF-Beta family signaling by inhibitory Smads
  • Keiji Miyazawa, Kohei Miyazono
  • 12. Structural basis of ligand-receptor interactions
  • Andrew Hinck, Thomas Müller, Tim Springer
  • 13. Structural basis of intracellular signaling process: receptors and Smads
  • Alex Bullock
  • 14. Non-Smad TGF-Beta family signaling
  • Ying Zhang
  • 15. Signaling crosstalk in TGF-Beta signaling
  • Kunxin Luo
  • 16. TGF-Beta family signaling in the control of cell proliferation and survival
  • Xiao-Fan Wang
  • 17. TGF-Beta family signaling in Drosophila
  • Mike O'Connor
  • 18. TGF-Beta family signaling in C. elegans
  • Cathy Savage-Dunn, Rick Padgett
  • 19. TGF-Beta family signaling in early vertebrate development
  • Liz Robertson
  • 20. TGF-Beta family signaling in embryonic and somatic stem cell renewal and differentiation
  • Jeff Wrana, Alan Mullen
  • 21. TGF-Beta family signaling in epithelial differentiation and epithelial-mesenchymal transition
  • Aris Moustakas
  • 22. TGF-Beta family signaling in mesenchymal differentiation
  • Brendan Lee, Yuji Mishina
  • 23. TGF-Beta family signaling in endothelial cell differentiation, vasculogenesis and angiogenesis
  • Peter ten Dijke
  • 24. TGF-Beta family signaling in the control of hematopoiesis
  • Stefan Karlsson, Ulrika Blank
  • 25. TGF-Beta family signaling in lymphocyte and immune cell differentiation and function
  • Shomyseh Sanjabi and Ming Li
  • 26. TGF-Beta family signaling in neural and neuronal differentiation, development and function
  • John Kessler
  • 27. Control of the reproductive system by TGF-Beta family signaling
  • Stephanie Pangas, Martin Matzuk
  • 28. TGF-Beta family signaling in connective tissue and skeletal diseases
  • Eileen Shore, Hal Dietz
  • 29. TGF-Beta family signaling in tumor suppression and cancer progression
  • Joan Seoane and Roger Gomis
  • 30. TGF-Beta signaling and the tumor micro-environment
  • Hal Moses
  • 31. TGF-Beta signaling and fibrosis
  • Hal Chapman
  • 32. TGF-Beta-based therapeutical approaches
  • Lalage Wakefield, Rosemary Akhurst
  • 33. Activin/myostatin-based therapeutic approaches
  • Se-Jin Lee, HQ Han
  • 34. BMP-based therapeutic approaches
  • Vicki Rosen.
Description
pages cm
Notes
Includes bibliographical references.
Technical Details
  • Staff View

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    a| Machine generated contents note: -- (preliminary) -- 1. The discovery and early days of TGF-Beta: a historical perspective. -- Hal Moses, Anita Roberts, Rik Derynck -- 2. TGF-Beta and the TGF-Beta family, context-dependent roles in cell and tissue physiology -- Kohei Miyazono, Rik Derynck -- 3. Activins and inhibins -- Chester Brown -- 4. Bone morphogenetic proteins -- Takenobu Katagiri, Tetsu Watabe -- 5. Regulation of the bioavailability of TGF-Beta and TGF-Beta-related proteins -- Dan Rifkin -- 6. Agonists and antagonists of TGF-Beta family ligands -- Chenbei Chang -- 7. TGF-Beta family receptors -- Calle Heldin and Aris Moustakas -- 8. TGF-Beta signaling from receptors to Smads -- Akiko Hata, Ye-Guang Chen -- 9. Transcriptional control by Smads -- Caroline Hill -- 10. Post-translational control of Smads -- Xin-Hua Feng -- 11. Regulation of TGF-Beta family signaling by inhibitory Smads -- Keiji Miyazawa, Kohei Miyazono -- 12. Structural basis of ligand-receptor interactions -- Andrew Hinck, Thomas Müller, Tim Springer -- 13. Structural basis of intracellular signaling process: receptors and Smads -- Alex Bullock -- 14. Non-Smad TGF-Beta family signaling -- Ying Zhang -- 15. Signaling crosstalk in TGF-Beta signaling -- Kunxin Luo -- 16. TGF-Beta family signaling in the control of cell proliferation and survival -- Xiao-Fan Wang -- 17. TGF-Beta family signaling in Drosophila -- Mike O'Connor -- 18. TGF-Beta family signaling in C. elegans -- Cathy Savage-Dunn, Rick Padgett -- 19. TGF-Beta family signaling in early vertebrate development -- Liz Robertson -- 20. TGF-Beta family signaling in embryonic and somatic stem cell renewal and differentiation -- Jeff Wrana, Alan Mullen -- 21. TGF-Beta family signaling in epithelial differentiation and epithelial-mesenchymal transition -- Aris Moustakas -- 22. TGF-Beta family signaling in mesenchymal differentiation -- Brendan Lee, Yuji Mishina -- 23. TGF-Beta family signaling in endothelial cell differentiation, vasculogenesis and angiogenesis -- Peter ten Dijke -- 24. TGF-Beta family signaling in the control of hematopoiesis -- Stefan Karlsson, Ulrika Blank -- 25. TGF-Beta family signaling in lymphocyte and immune cell differentiation and function -- Shomyseh Sanjabi and Ming Li -- 26. TGF-Beta family signaling in neural and neuronal differentiation, development and function -- John Kessler -- 27. Control of the reproductive system by TGF-Beta family signaling -- Stephanie Pangas, Martin Matzuk -- 28. TGF-Beta family signaling in connective tissue and skeletal diseases -- Eileen Shore, Hal Dietz -- 29. TGF-Beta family signaling in tumor suppression and cancer progression -- Joan Seoane and Roger Gomis -- 30. TGF-Beta signaling and the tumor micro-environment -- Hal Moses -- 31. TGF-Beta signaling and fibrosis -- Hal Chapman -- 32. TGF-Beta-based therapeutical approaches -- Lalage Wakefield, Rosemary Akhurst -- 33. Activin/myostatin-based therapeutic approaches -- Se-Jin Lee, HQ Han -- 34. BMP-based therapeutic approaches -- Vicki Rosen.
    520
      
      
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    520
      
      
    a| "Members of the transforming growth factor β (TGFβ) family, which include activins and bone morphogenetic proteins (BMPs), are essential intercellular signaling molecules that control of cell proliferation and embryonic development. This book provides a comprehensive view of the different members of the TGFβ family and their receptors, as well as their roles in normal physiology and development and pathological conditions such as cancer"-- c| Provided by publisher.
    650
      
    0
    a| Transforming growth factors-beta.
    650
      
    7
    a| SCIENCE / Life Sciences / Biology / Developmental Biology. 2| bisacsh
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    a| SCIENCE / Life Sciences / Biology / Molecular Biology. 2| bisacsh
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    a| Derynck, Rik, e| editor.
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    a| Miyazono, Kōhei, d| 1956- e| editor.
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    a| QP552 .T72 B56 2017 w| LC i| 7232896-1001 l| NOTORDERED m| SCI-ENG t| BOOK
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