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Structure and Mechanism in Protein Science: A Guide to Enzyme Catalysis and Protein Folding

Alan Fersht
Format
Book
Published
New Jersey : World Scientific, 2017.
Language
English
Series
Series in Structural Biology
ISBN
9789813225183 (hardcover : alk. paper), 9813225181 (hardcover : alk. paper), 9789813225190 (pbk. : alk. paper), 981322519X (pbk. : alk. paper)
Contents
  • The three-dimensional structure of proteins
  • Chemical catalysis
  • The basic equations of enzyme kinetics
  • Measurement and magnitude of individual rate constants
  • The pH dependence of enzyme catalysis
  • Practical methods for kinetics and equilibria
  • Detection of intermediates in enzymatic reactions
  • Stereochemistry of enzymatic reactions
  • Active-site-directed and enzyme-activated irreversible inhibitors : "affinity labels" and "suicide inhibitors"
  • Conformational change, allosteric regulation, motors, and work
  • Forces between molecules, and binding energies
  • Enzyme-substrate complementarity and the use of binding energy in catalysis
  • Specificity and editing mechanisms
  • Recombinant DNA technology
  • Protein engineering
  • Case studies of enzyme structure and mechanism
  • Protein stability
  • Kinetics of protein folding
  • Folding pathways and energy landscapes.
Description
p. ; cm.
Notes
Includes bibliographical references and index.
Series Statement
Series in structural biology ; vol. 9
Series in structural biology ; v. 9
Technical Details
  • Staff View

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    a| Structure and mechanism in protein science : b| a guide to enzyme catalysis and protein folding / c| Alan Fersht.
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    a| New Jersey : b| World Scientific, c| 2017.
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    a| p. ; c| cm.
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    a| text 2| rdacontent
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    a| unmediated 2| rdamedia
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    a| volume 2| rdacarrier
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    a| Series in structural biology ; v| vol. 9
    504
      
      
    a| Includes bibliographical references and index.
    505
    0
      
    a| The three-dimensional structure of proteins -- Chemical catalysis -- The basic equations of enzyme kinetics -- Measurement and magnitude of individual rate constants -- The pH dependence of enzyme catalysis -- Practical methods for kinetics and equilibria -- Detection of intermediates in enzymatic reactions -- Stereochemistry of enzymatic reactions -- Active-site-directed and enzyme-activated irreversible inhibitors : "affinity labels" and "suicide inhibitors" -- Conformational change, allosteric regulation, motors, and work -- Forces between molecules, and binding energies -- Enzyme-substrate complementarity and the use of binding energy in catalysis -- Specificity and editing mechanisms -- Recombinant DNA technology -- Protein engineering -- Case studies of enzyme structure and mechanism -- Protein stability -- Kinetics of protein folding -- Folding pathways and energy landscapes.
    650
    1
    2
    a| Protein Conformation
    650
    2
    2
    a| Enzymes x| chemistry
    650
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    2
    a| Catalysis
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    2
    a| Protein Folding
    830
      
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    a| Series in structural biology ; v| v. 9.
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    a| QD431.25 .S85 w| LC i| 7217767-1001 l| NOTORDERED m| SCI-ENG t| BOOK
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