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Protein Amyloid Aggregation [electronic resource]: Methods and Protocols

edited by David Eliezer, Weill Cornell Medical College, New York, NY, USA
Format
EBook; Book; Online
Published
New York : Humana Press ; Springer, [2015]
Language
English
Series
Methods in Molecular Biology
Springer Protocols
Methods in Molecular Biology (Clifton, N.J.)
Springer Protocols (Series)
ISBN
9781493929771, 1493929771, 9781493929788
Summary
This detailed volume focuses on methods for the characterization of aggregation processes that lead to the formation of amyloid fibrils and amyloid oligomers which feature in the etiology of a variety of human disorders collectively known as amyloidoses. The scope of the collection includes techniques for visualizing early steps on the amyloid formation pathway, methods for capturing and characterizing oligomeric, potentially toxic, intermediates, strategies for preparing and characterizing mature amyloid fibrils, and approaches for understanding templating and transmission of amyloid aggregates. Written in the highly successful Methods in Molecular Biology series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Protein Amyloid Aggregation: Methods and Protocols serves as an ideal guide for biochemists and biophysicists with an interest in elucidating the mechanisms of protein amyloid formation, as well as chemists, pharmacologists, and clinicians with an interest in leveraging an understanding of such mechanisms for the purpose of therapeutic development.
Description
Mode of access: World wide Web.
Notes
Includes bibliographical references and index.
Series Statement
Methods in molecular biology, 1064-3745 ; volume 1345
Springer protocols, 1949-2448
Methods in molecular biology (Clifton, N.J.) ; v. 1345, 1064-3745
Springer protocols (Series) 1949-2448
Copyright Not EvaluatedCopyright Not Evaluated
Technical Details
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    a| Protein amyloid aggregation h| [electronic resource] : b| methods and protocols / c| edited by David Eliezer, Weill Cornell Medical College, New York, NY, USA.
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