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Gene Therapy for Neurological Disorders [electronic resource]: Methods and Protocols

edited by Fredric P. Manfredsson. Translational Science and Molecular Medicine, Michigan State University, College of Human Science, Grand Rapids, Michigan, USA
Format
EBook; Book; Online
Published
New York : Humana Press, [2016]
Language
English
Series
Methods in Molecular Biology
Springer Protocols
Methods in Molecular Biology (Clifton, N.J.)
Springer Protocols (Series)
ISBN
9781493932702, 1493932705, 9781493932719 (eBook), 1493932713 (eBook)
Contents
  • Introduction to viral vectors and other delivery methods for gene therapy of the nervous system / Fredric P. Manfredsson
  • Delivering transgenic DNA exceeding the carrying capacity of AAV vectors / Matthew L. Hirsch, Sonya J. Wolf, and R.J. Samulski
  • Expression of multiple functional RNAs or proteins from one viral vector / Tomas Björklund
  • Regulated gene therapy / Ludivine Breger [and others]
  • Design of shRNA and miRNA for delivery to the CNS / Gabriela Toro Cabrera and Christian Mueller
  • Tissue-specific promoters in the CNS / Sebastian Kügler
  • Small-scale recombinant adeno-associated virus purification / Corinna Burger and Kevin R. Nash
  • Lentivirus production and purification / Matthew J. Benskey and Fredric P. Manfredsson
  • Viral vector production : adenovirus / Julius W. Kim [and others]
  • Controlling AAV tropism in the nervous system with natural and engineered capsids / Michael J. Castle [and others]
  • Altering tropism of rAAV by directed evolution / Damien Marsic and Sergei Zolotukhin
  • Altering entry site preference of lentiviral vectors into neuronal cells by pseudotyping with envelope glycoproteins / Kenta Kobayashi [and others]
  • Directed evolution of adenoviruses / Jason G. Smith
  • Intraparenchymal stereotaxic delivery of rAAV and special considerations in vector handling / Matthew J. Benskey and Fredric P. Manfredsson
  • MRI-guided delivery of viral vectors / Ernesto A. Salegio, John Bringas, and Krystof S. Bankiewicz
  • Systemic gene therapy for targeting the CNS / Sara E. Gombash and Kevin D. Foust
  • Widespread neuronal transduction of the rodent CNS via neonatal viral injection / Ji-Yoen Kim, Stacy D. Grunke, and Joanna L. Jankowsky
  • AAV-mediated gene transfer to dorsal root ganglion / Hongwei Yu, Gregory Fischer, and Quinn H. Hogan
  • Gene therapy of the peripheral nervous system : the enteric nervous system / Matthew J. Benskey and Fredric P. Manfredsson
  • Gene therapy of the peripheral nervous system : celiac ganglia / Bradley Hammond and David L. Kreulen
  • Convection enhanced delivery of recombinant adeno-associated virus into the mouse brain / Kevin R. Nash and Marcia N. Gordon
  • Nonviral gene therapy of the nervous system : electroporation / Xue-Feng Ding and Ming Fan
  • Non-viral, lipid-mediated DNA and mRNA gene therapy of the central nervous system (CNS) : chemical-based transfection / James G. Hecker
  • Ex vivo gene therapy using human mesenchymal stem cells to deliver growth factors in the skeletal muscle of a familial ALS rat model / Masatoshi Suzuki and Clive N. Svendsen
  • Gene therapy models of Alzheimer's disease and other dementias / Benjamin Combs, Andrew Kneynsberg, and Nicholas M. Kanaan
  • Viral vector-based modeling of neurodegenerative disorders : Parkinson's disease / D. Luke Fischer [and others]
  • Gene therapy-based modeling of neurodegenerative disorders : Huntington's disease / Deborah Young
  • Gene therapy for the treatment of neurological disorders : amyotrophic lateral Sslerosis / Zachary T. McEachin, Anthony Donsante, and Nicholas Boulis
  • Stereotaxic surgical targeting of the nonhuman primate caudate and putamen : gene therapy for Huntington's disease / Jodi L. McBride and Randall L. Clark
  • Gene therapy for the treatment of neurological disorders : metabolic disorders / Dominic J. Gessler and Guangping Gao
  • Gene therapy for the treatment of neurological disorders : central nervous system neoplasms / Neha Kamran [and others]
  • AAV2-neurturin for Parkinson's disease : what lessons have we learned? / Jeffrey H. Kordower.
Description
Mode of access: World wide Web.
Notes
Includes bibliographical references and index.
Series Statement
Methods in molecular biology, 1064-3745 ; 1382
Methods in molecular biology (Clifton, N.J.) ; v. 1382
Copyright Not EvaluatedCopyright Not Evaluated
Technical Details
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    t| Introduction to viral vectors and other delivery methods for gene therapy of the nervous system / r| Fredric P. Manfredsson -- t| Delivering transgenic DNA exceeding the carrying capacity of AAV vectors / r| Matthew L. Hirsch, Sonya J. Wolf, and R.J. Samulski -- t| Expression of multiple functional RNAs or proteins from one viral vector / r| Tomas Björklund -- t| Regulated gene therapy / r| Ludivine Breger [and others] -- t| Design of shRNA and miRNA for delivery to the CNS / r| Gabriela Toro Cabrera and Christian Mueller -- t| Tissue-specific promoters in the CNS / r| Sebastian Kügler -- t| Small-scale recombinant adeno-associated virus purification / r| Corinna Burger and Kevin R. Nash -- t| Lentivirus production and purification / r| Matthew J. Benskey and Fredric P. Manfredsson -- t| Viral vector production : adenovirus / r| Julius W. Kim [and others] -- t| Controlling AAV tropism in the nervous system with natural and engineered capsids / r| Michael J. Castle [and others] -- t| Altering tropism of rAAV by directed evolution / r| Damien Marsic and Sergei Zolotukhin -- t| Altering entry site preference of lentiviral vectors into neuronal cells by pseudotyping with envelope glycoproteins / r| Kenta Kobayashi [and others] -- t| Directed evolution of adenoviruses / r| Jason G. Smith -- t| Intraparenchymal stereotaxic delivery of rAAV and special considerations in vector handling / r| Matthew J. Benskey and Fredric P. Manfredsson -- t| MRI-guided delivery of viral vectors / r| Ernesto A. Salegio, John Bringas, and Krystof S. Bankiewicz -- t| Systemic gene therapy for targeting the CNS / r| Sara E. Gombash and Kevin D. Foust -- t| Widespread neuronal transduction of the rodent CNS via neonatal viral injection / r| Ji-Yoen Kim, Stacy D. Grunke, and Joanna L. Jankowsky -- t| AAV-mediated gene transfer to dorsal root ganglion / r| Hongwei Yu, Gregory Fischer, and Quinn H. Hogan -- t| Gene therapy of the peripheral nervous system : the enteric nervous system / r| Matthew J. Benskey and Fredric P. Manfredsson -- t| Gene therapy of the peripheral nervous system : celiac ganglia / r| Bradley Hammond and David L. Kreulen -- t| Convection enhanced delivery of recombinant adeno-associated virus into the mouse brain / r| Kevin R. Nash and Marcia N. Gordon -- t| Nonviral gene therapy of the nervous system : electroporation / r| Xue-Feng Ding and Ming Fan -- t| Non-viral, lipid-mediated DNA and mRNA gene therapy of the central nervous system (CNS) : chemical-based transfection / r| James G. Hecker -- t| Ex vivo gene therapy using human mesenchymal stem cells to deliver growth factors in the skeletal muscle of a familial ALS rat model / r| Masatoshi Suzuki and Clive N. Svendsen -- t| Gene therapy models of Alzheimer's disease and other dementias / r| Benjamin Combs, Andrew Kneynsberg, and Nicholas M. Kanaan -- t| Viral vector-based modeling of neurodegenerative disorders : Parkinson's disease / r| D. Luke Fischer [and others] -- t| Gene therapy-based modeling of neurodegenerative disorders : Huntington's disease / r| Deborah Young -- t| Gene therapy for the treatment of neurological disorders : amyotrophic lateral Sslerosis / r| Zachary T. McEachin, Anthony Donsante, and Nicholas Boulis -- t| Stereotaxic surgical targeting of the nonhuman primate caudate and putamen : gene therapy for Huntington's disease / r| Jodi L. McBride and Randall L. Clark -- t| Gene therapy for the treatment of neurological disorders : metabolic disorders / r| Dominic J. Gessler and Guangping Gao -- t| Gene therapy for the treatment of neurological disorders : central nervous system neoplasms / r| Neha Kamran [and others] -- t| AAV2-neurturin for Parkinson's disease : what lessons have we learned? / r| Jeffrey H. Kordower.
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    a| Nervous System Diseases x| Genetics.
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