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Some Antiviral and Antineoplastic Drugs, and Other Pharmaceutical Agents [electronic resource]

IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
Format
EBook; Book; Online
Published
Geneva 27 : World Health Organization Jan. 2000 Ipswich : Ebsco Publishing [Distributor]
Language
English
ISBN
9789283215769, 9283215761 (E-Book)
Summary
Annotation
Description
Mode of access: World wide Web.
Copyright Not EvaluatedCopyright Not Evaluated
Technical Details
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    a| 9283215761 (E-Book) c| USD 55.00 Retail Price (Ebsco Publishing) 9| Active Record
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    a| Some Antiviral and Antineoplastic Drugs, and Other Pharmaceutical Agents h| [electronic resource]
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    a| Geneva 27 : b| World Health Organization c| Jan. 2000 a| Ipswich : b| Ebsco Publishing [Distributor]
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    a| Annotation b| Evaluates the carcinogenic risks to humans posed by the use of four antiretroviral agents, four DNA topoisomerase II inhibitors used in the treatment of cancer, and an additional three pharmaceutical agents (hydroxyures, phenolphthalein, and vitamin K substances). The volume marks the first IARC evaluation of nucleoside analogs that act as antiviral agents. The evaluation responds in part to recent findings that zidovudine (AZT), an effective antiretroviral agent now being given to pregnant HIV-infected women to prevent maternal-to-fetal transmission of the virus, is a transplacental carcinogen in mice. The opening monograph evaluates the carcinogenicity to humans of the antiretroviral nucleoside analogs zidovudine (AZT), zalcitabine (ddC), and didanosine (ddI), and the antiherpesvirus drug aciclovir. Of these, aciclovir and didanosine could not be classified on the basis of available data. For zidovudine, transplacental administration to mice resulted in an increased incidence and multiplicity of lung and liver tumours and in an increased incidence of female reproductive tract tumours in one study, but not in another involving treatment at a lower dose.
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    a| IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
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