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Rheumatology

[edited by] Marc C. Hochberg, Alan J. Silman, Josef S. Smolen, Michael E. Weinblatt, Michael H. Weisman
Format
EBook; Book; Online
Published
Philadelphia, PA : Mosby/Elsevier, [2015]
Edition
Sixth edition
Language
English
ISBN
9780323091381 (2 Volume set), 0323091385 (2 Volume set), 9789996093043, 9996093042, 9789996092985, 9996092984
Access Restriction
Electronic access is available for UVA students, faculty, staff, and affiliates only. IP address verification required.
Summary
Stay current in the ever-changing discipline of rheumatology with clear, reliable guidance from Hochberg's Rheumatology, one of the most respected and trusted sources in the field. Designed to meet the needs of the practicing clinician, this medical reference book provides extensive, authoritative coverage of rheumatic diseases from basic scientific principles to practical points of clinical management in a lucid, logical, user-friendly manner. Track disease progression and treat patients more effectively with the information on genetic findings, imaging outcomes, cell and biologic therapies, rheumatoid arthritis, and SLE. Incorporate recent findings about pathogenesis of disease; imaging outcomes for specific diseases like RA, osteoarthritis, and spondyloarthropathies; cell and biologic therapies; and other timely topics.
Contents
  • Epidemiologic concepts and classification of rheumatic and musculoskeletal conditions
  • Principles of clinical outcome assessment
  • Principles of health economics and application to rheumatic disorders
  • The synovium
  • Articular cartilage
  • Bone structure and function
  • Tendons and ligaments
  • Connective tissue responses to mechanical stress
  • Biomechanics of peripheral joints
  • Biomechanics of the spine
  • Principles of genetic epidemiology
  • Principles and techniques in molecular biology
  • Cytokines
  • Signal transduction in immune cells
  • Principles of adaptive immunity
  • Principles of innate immunity
  • Systems biology
  • Epigenetics in rheumatology
  • The microbiome in rheumatic diseases
  • Tissue destruction and repair
  • Principles of tissue engineering and cell- and gene-based therapy
  • Osteoimmunology
  • Inflammation and its mediators
  • Scientific basis of pain
  • Effects of the neuroendocrine system on development and function of the immune system
  • Interpreting the medical literature for the rheumatologist: Study design and levels of evidence
  • Ethics in clinical trials
  • History and physical examination
  • Pattern recognition in arthritis
  • Role of laboratory tests in rheumatic disorders
  • Synovial fluid analysis
  • Minimally invasive procedures
  • Skin in rheumatic disease
  • The eye in rheumatic disease
  • The heart in rheumatic disease
  • The lung in rheumatic disease
  • Gastrointestinal tract and rheumatic disease
  • The kidney and rheumatic disease
  • The nervous system in rheumatic disease
  • Conventional radiography and computed tomography
  • Functional magnetic resonance imaging
  • Musculoskeletal ultrasound
  • Bone scintigraphy and positron emission tomography
  • Dual x-ray absorptiometry and measurement of bone
  • Use of imaging as an outcome measure in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis in clinical trials
  • Arthritis patient education, health promotion, and team approaches to management
  • Principles of rehabilitation: Physical and occupational therapy
  • Complementary and alternative medicine
  • Placebos, caring, and healing in rheumatology
  • Drug development
  • Nonpharmacologic pain management
  • Pharmacogenomics in rheumatology
  • -- Principles of opioid treatment of chronic musculoskeletal pain
  • Nonsteroidal antiinflammatory drugs
  • Systemic glucocorticoids in rheumatology
  • Nonimmunosuppressive disease-modifying antirheumatic drugs
  • Methotrexate *
  • Leflunomide
  • Immunosuppressives: Cyclosporine, cyclophosphamide, azathioprine, mycophenolate mofetil
  • T-cell costimulation and other directed therapies
  • B-cell depletion
  • Cytokine neutralizers: Interleukin-1 inhibitors
  • Interleukin-6 inhibition
  • Tumor necrosis factor-blocking therapies
  • Kinase inhibition: A new therapeutic principle in rheumatology
  • Emerging therapeutic targets: GM-CSF, IL-17, and IL-23
  • Biosimilars in rheumatology
  • Infections and biologic therapy for rheumatoid arthritis: An update on risk and prevention
  • Drugs and pregnancy
  • Aspiration and injection of joints and periarticular tissue and intralesional therapy
  • Perioperative care of patients with rheumatic disease
  • Neck pain
  • Lumbar spine disorders --The shoulder
  • The elbow
  • The wrist and hand
  • The hip
  • The knee
  • The ankle and foot
  • The temporomandibular joint
  • Fibromyalgia and related syndromes
  • Entrapment neuropathies and compartment syndromes
  • Complex regional pain syndrome
  • Classification and epidemiology of rheumatoid arthritis
  • Preclinical features of rheumatoid arthritis
  • Clinical features of rheumatoid arthritis
  • Extraarticular features of rheumatoid arthritis and systemic involvement
  • Adult-onset Still disease
  • Imaging of rheumatoid arthritis
  • The contribution of genetic factors to rheumatoid arthritis
  • Animal models of arthritis
  • Autoantibodies in rheumatoid arthritis
  • Cellular immunity in rheumatoid arthritis
  • Angiogenesis and vasculogenesis in rheumatoid arthritis
  • The rheumatoid joint: Synovitis and tissue destruction
  • Evaluation and management of early inflammatory polyarthritis
  • Evaluation and outcomes of patients with rheumatoid arthritis
  • Management of rheumatoid arthritis: synovitis
  • Multidisciplinary approach to rheumatoid arthritis
  • Evaluation of musculoskeletal complaints in children: Clinical evaluation
  • Evaluation of musculoskeletal complaints in children: Nonautoimmune musculoskeletal disorders
  • Classification and epidemiology of juvenile idiopathic arthritis
  • Clinical features of juvenile idiopathic arthritis
  • -- Etiology and pathogenesis of juvenile idiopathic arthritis
  • Management of juvenile idiopathic arthritis
  • Juvenile-onset spondyloarthritis
  • Connective tissue diseases in children
  • Rehabilitation and psychosocial issues in juvenile idiopathic arthritis
  • Infectious arthritis I: Bacterial arthritis
  • Infectious arthritis II: Mycobacterial, brucellar, fungal, and parasitic arthritis
  • Lyme disease
  • Rheumatologic aspects of viral infections
  • Acute rheumatic fever
  • Reactive arthritis
  • Classification and epidemiology of spondyloarthritis
  • Clinical features of axial spondyloarthritis
  • Etiology, pathogenesis, and pathophysiology of ankylosing spondylitis
  • Genetics of axial spondyloarthritis
  • Imaging in spondyloarthritis
  • Management of ankylosing spondylitis/axial spondyloarthritis
  • Classification and epidemiology of psoriatic arthritis
  • Clinical features of psoriatic arthritis
  • Etiology and pathogenesis of psoriatic arthritis
  • Management of psoriatic arthritis
  • Enthesopathies
  • Epidemiology and classification of systemic lupus erythematosus
  • Preclinical features of lupus
  • Clinical features of systemic lupus erythematosus
  • Genetics of lupus
  • Immunopathology of systemic lupus erythematosus
  • Animal models of lupus
  • Autoantibodies in systemic lupus erythematosus
  • Pathogenesis of lupus
  • Drug-induced lupus
  • Assessing disease activity and outcome in systemic lupus erythematosus
  • Management of nonrenal and non-central nervous system lupus
  • Treatment of neuropsychiatric lupus
  • Systemic lupus erythematosus: Treatment-renal involvement
  • Systemic lupus erythematosus in the pregnant patient and neonatal lupus
  • Sjögren syndrome
  • Antiphospholipid syndrome: Overview of pathogenesis, diagnosis, and management
  • Classification and epidemiology of scleroderma
  • Assessing disease activity and outcome in systemic sclerosis (scleroderma)
  • Clinical features of systemic sclerosis
  • Etiology and pathogenesis of systemic sclerosis
  • Management of systemic sclerosis
  • Pulmonary management of systemic sclerosis
  • Raynaud phenomenon
  • Localized scleroderma and scleroderma-like syndromes
  • Clinical features, classification, and epidemiology of inflammatory muscle disease
  • Inflammatory muscle disease: etiology and pathogenesis
  • Management of inflammatory muscle disease
  • Metabolic, drug-induced, and other noninflammatory myopathies
  • Overlap syndromes
  • Classification and epidemiology of vasculitis
  • Biology and immunopathogenesis of vasculitis
  • Polyarteritis nodosa and Cogan syndrome
  • Polymyalgia rheumatica and giant cell arteritis
  • Antineutrophil cytoplasmic antibody-associated vasculitis
  • Takayasu arteritis
  • Behçet syndrome
  • Kawasaki disease
  • Henoch-Schönlein purpura/immunoglobulin-A vasculitis
  • -- Cutaneous vasculitis and panniculitis
  • Cryoglobulinemia
  • Primary angiitis of the central nervous system
  • Monogenic autoinflammatory diseases
  • Sarcoidosis
  • Relapsing polychondritis
  • Amyloidosis
  • Digital clubbing and hypertrophic osteoarthropathy
  • Miscellaneous arthropathies
  • Osteoarthritis: Epidemiology and classification
  • Local and systemic risk factors for incidence and progression of osteoarthritis
  • Clinical features of osteoarthritis
  • Animal models of osteoarthritis
  • Pathogenesis and pathology of osteoarthritis
  • Genetics of osteoarthritis
  • Imaging of osteoarthritis
  • Assessment of the patient with osteoarthritis and measurement of outcomes
  • Preclinical osteoarthritis
  • Assessment of imaging outcomes in osteoarthritis
  • Management of osteoarthritis
  • Diffuse idiopathic skeletal hyperostosis
  • Neuropathic arthropathy
  • Osteonecrosis
  • Rare osteoarthritis: Ochronosis and Kashin-Beck disease
  • Epidemiology of gout
  • Etiology and pathogenesis of gout
  • Clinical gout
  • Management of gout and hyperuricemia
  • Calcium pyrophosphate crystal-associated arthropathy
  • Basic calcium phosphate crystal deposition disease
  • Other crystal-related arthropathies
  • Rheumatoid manifestations of endocrine and lipid disease
  • Hemophilia and von Willebrand disease
  • Joint and bone lesions in hemoglobinopathies
  • Hemochromatosis
  • Epidemiology and classification of osteoporosis
  • Clinical features of osteoporosis
  • Pathophysiology of osteoporosis
  • Biochemical markers in bone disease
  • Management of osteoporosis
  • Glucocorticoid-induced osteoporosis
  • Osteomalacia and rickets
  • Primary hyperparathyroidism: Rheumatologic manifestations and bone disease
  • Renal osteodystrophy
  • Paget disease of bone
  • Gaucher disease
  • Mucopolysaccharidoses
  • Heritable connective tissue disorders
  • Hypermobility syndrome
  • Skeletal dysplasias
  • Bone tumors.
Description
1 online resource (xxv, 1743 pages) : illustrations (chiefly color)
Notes
Includes bibliographical references.
Copyright Not EvaluatedCopyright Not Evaluated
Technical Details
  • Access in Virgo Classic
  • Staff View

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    a| Principles of opioid treatment of chronic musculoskeletal pain -- Nonsteroidal antiinflammatory drugs -- Systemic glucocorticoids in rheumatology -- Nonimmunosuppressive disease-modifying antirheumatic drugs -- Methotrexate * -- Leflunomide -- Immunosuppressives: Cyclosporine, cyclophosphamide, azathioprine, mycophenolate mofetil -- T-cell costimulation and other directed therapies -- B-cell depletion -- Cytokine neutralizers: Interleukin-1 inhibitors -- Interleukin-6 inhibition -- Tumor necrosis factor-blocking therapies -- Kinase inhibition: A new therapeutic principle in rheumatology -- Emerging therapeutic targets: GM-CSF, IL-17, and IL-23 -- Biosimilars in rheumatology -- Infections and biologic therapy for rheumatoid arthritis: An update on risk and prevention -- Drugs and pregnancy -- Aspiration and injection of joints and periarticular tissue and intralesional therapy -- Perioperative care of patients with rheumatic disease -- Neck pain -- Lumbar spine disorders --The shoulder -- The elbow -- The wrist and hand -- The hip -- The knee -- The ankle and foot -- The temporomandibular joint -- Fibromyalgia and related syndromes -- Entrapment neuropathies and compartment syndromes -- Complex regional pain syndrome -- Classification and epidemiology of rheumatoid arthritis -- Preclinical features of rheumatoid arthritis -- Clinical features of rheumatoid arthritis -- Extraarticular features of rheumatoid arthritis and systemic involvement -- Adult-onset Still disease -- Imaging of rheumatoid arthritis -- The contribution of genetic factors to rheumatoid arthritis -- Animal models of arthritis -- Autoantibodies in rheumatoid arthritis -- Cellular immunity in rheumatoid arthritis -- Angiogenesis and vasculogenesis in rheumatoid arthritis -- The rheumatoid joint: Synovitis and tissue destruction -- Evaluation and management of early inflammatory polyarthritis -- Evaluation and outcomes of patients with rheumatoid arthritis -- Management of rheumatoid arthritis: synovitis -- Multidisciplinary approach to rheumatoid arthritis -- Evaluation of musculoskeletal complaints in children: Clinical evaluation -- Evaluation of musculoskeletal complaints in children: Nonautoimmune musculoskeletal disorders -- Classification and epidemiology of juvenile idiopathic arthritis -- Clinical features of juvenile idiopathic arthritis --
    505
    0
      
    a| Etiology and pathogenesis of juvenile idiopathic arthritis -- Management of juvenile idiopathic arthritis -- Juvenile-onset spondyloarthritis -- Connective tissue diseases in children -- Rehabilitation and psychosocial issues in juvenile idiopathic arthritis -- Infectious arthritis I: Bacterial arthritis -- Infectious arthritis II: Mycobacterial, brucellar, fungal, and parasitic arthritis -- Lyme disease -- Rheumatologic aspects of viral infections -- Acute rheumatic fever -- Reactive arthritis -- Classification and epidemiology of spondyloarthritis -- Clinical features of axial spondyloarthritis -- Etiology, pathogenesis, and pathophysiology of ankylosing spondylitis -- Genetics of axial spondyloarthritis -- Imaging in spondyloarthritis -- Management of ankylosing spondylitis/axial spondyloarthritis -- Classification and epidemiology of psoriatic arthritis -- Clinical features of psoriatic arthritis -- Etiology and pathogenesis of psoriatic arthritis -- Management of psoriatic arthritis -- Enthesopathies -- Epidemiology and classification of systemic lupus erythematosus -- Preclinical features of lupus -- Clinical features of systemic lupus erythematosus -- Genetics of lupus -- Immunopathology of systemic lupus erythematosus -- Animal models of lupus -- Autoantibodies in systemic lupus erythematosus -- Pathogenesis of lupus -- Drug-induced lupus -- Assessing disease activity and outcome in systemic lupus erythematosus -- Management of nonrenal and non-central nervous system lupus -- Treatment of neuropsychiatric lupus -- Systemic lupus erythematosus: Treatment-renal involvement -- Systemic lupus erythematosus in the pregnant patient and neonatal lupus -- Sjögren syndrome -- Antiphospholipid syndrome: Overview of pathogenesis, diagnosis, and management -- Classification and epidemiology of scleroderma -- Assessing disease activity and outcome in systemic sclerosis (scleroderma) -- Clinical features of systemic sclerosis -- Etiology and pathogenesis of systemic sclerosis -- Management of systemic sclerosis -- Pulmonary management of systemic sclerosis -- Raynaud phenomenon -- Localized scleroderma and scleroderma-like syndromes -- Clinical features, classification, and epidemiology of inflammatory muscle disease -- Inflammatory muscle disease: etiology and pathogenesis -- Management of inflammatory muscle disease -- Metabolic, drug-induced, and other noninflammatory myopathies -- Overlap syndromes -- Classification and epidemiology of vasculitis -- Biology and immunopathogenesis of vasculitis -- Polyarteritis nodosa and Cogan syndrome -- Polymyalgia rheumatica and giant cell arteritis -- Antineutrophil cytoplasmic antibody-associated vasculitis -- Takayasu arteritis -- Behçet syndrome -- Kawasaki disease -- Henoch-Schönlein purpura/immunoglobulin-A vasculitis --
    505
    0
      
    a| Cutaneous vasculitis and panniculitis -- Cryoglobulinemia -- Primary angiitis of the central nervous system -- Monogenic autoinflammatory diseases -- Sarcoidosis -- Relapsing polychondritis -- Amyloidosis -- Digital clubbing and hypertrophic osteoarthropathy -- Miscellaneous arthropathies -- Osteoarthritis: Epidemiology and classification -- Local and systemic risk factors for incidence and progression of osteoarthritis -- Clinical features of osteoarthritis -- Animal models of osteoarthritis -- Pathogenesis and pathology of osteoarthritis -- Genetics of osteoarthritis -- Imaging of osteoarthritis -- Assessment of the patient with osteoarthritis and measurement of outcomes -- Preclinical osteoarthritis -- Assessment of imaging outcomes in osteoarthritis -- Management of osteoarthritis -- Diffuse idiopathic skeletal hyperostosis -- Neuropathic arthropathy -- Osteonecrosis -- Rare osteoarthritis: Ochronosis and Kashin-Beck disease -- Epidemiology of gout -- Etiology and pathogenesis of gout -- Clinical gout -- Management of gout and hyperuricemia -- Calcium pyrophosphate crystal-associated arthropathy -- Basic calcium phosphate crystal deposition disease -- Other crystal-related arthropathies -- Rheumatoid manifestations of endocrine and lipid disease -- Hemophilia and von Willebrand disease -- Joint and bone lesions in hemoglobinopathies -- Hemochromatosis -- Epidemiology and classification of osteoporosis -- Clinical features of osteoporosis -- Pathophysiology of osteoporosis -- Biochemical markers in bone disease -- Management of osteoporosis -- Glucocorticoid-induced osteoporosis -- Osteomalacia and rickets -- Primary hyperparathyroidism: Rheumatologic manifestations and bone disease -- Renal osteodystrophy -- Paget disease of bone -- Gaucher disease -- Mucopolysaccharidoses -- Heritable connective tissue disorders -- Hypermobility syndrome -- Skeletal dysplasias -- Bone tumors.
    520
      
      
    a| Stay current in the ever-changing discipline of rheumatology with clear, reliable guidance from Hochberg's Rheumatology, one of the most respected and trusted sources in the field. Designed to meet the needs of the practicing clinician, this medical reference book provides extensive, authoritative coverage of rheumatic diseases from basic scientific principles to practical points of clinical management in a lucid, logical, user-friendly manner. Track disease progression and treat patients more effectively with the information on genetic findings, imaging outcomes, cell and biologic therapies, rheumatoid arthritis, and SLE. Incorporate recent findings about pathogenesis of disease; imaging outcomes for specific diseases like RA, osteoarthritis, and spondyloarthropathies; cell and biologic therapies; and other timely topics.
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