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Osteoporosis

edited by Robert Marcus, David Feldman, David W. Dempster, Marjorie Luckey, Jane A. Cauley
Format
EBook; Book; Online
Published
Amsterdam : Elsevier/Academic Press, 2013.
Edition
Fourth edition
Language
English
ISBN
9780123982520, 0123982529, 1299668232, 9781299668232, 9780124158535, 0124158536
Access Restriction
Electronic access is available for UVA students, faculty, staff, and affiliates only. IP address verification required.
Summary
Now in its third edition, Osteoporosis, is the most comprehensive, authoritative reference on this disease. Written by renowned experts in the field, this two-volume reference is a must-have for academic and medical libraries, physicians, researchers, and any company involved in osteoporosis research and development. Worldwide, 200 million women between 60-80 suffer from osteoporosis and have a lifetime risk of fracture between 30 and 40 % continuing to make osteoporosis a hot topic in medicine.
Contents
  • V: 1
  • The bone organ system: form and function
  • The nature of osteoporosis
  • Reflections on osteoporosis
  • Reflections on development of concepts of intercellular communication in bone
  • Osteo-odyssey: a memoir
  • Development of the skeleton
  • The skeletal stem cell
  • Osteoclast biology
  • Osteoblast biology
  • Osteocyte biology
  • The regulatory role of matrix protein in mineralization of bone
  • Parathyroid hormone and parathyroid hormone-related protein
  • Vitamin D: biology, actions, and clinical implications
  • Regulation of bone cell function by estrogens
  • Androgens and skeletal biology: basic mechanisms
  • Phosphatonins
  • Skeletal growth factors
  • Wnt signaling in skeletal homeostasis and diseases
  • The mechanical behavior of bone
  • Cellular and molecular mechanotransduction in bone
  • Adaptation of skeletal structure to mechanical loading
  • Biomechanics of hip and vertebral fractures
  • Prevention of osteoporosis by physical signals: defining a potential role for nondrug strategies in the treatment of musculoskeletal injury and disease
  • Epidemiologic methods in studies of osteoporosis
  • Genetic determinants of osteoporosis
  • Race, ethnicity, and osteoporosis
  • Geographic variability in hip and vertebral fractures
  • Nutrition and risk for osteoporosis
  • Physical activity and exercise in the maintenance of the adult skeleton and the prevention of osteoporotic fractures
  • Premenopausal reproductive and hormonal characteristics and the risk for osteoporosis
  • Clinical and epidemiological studies: skeletal changes across menopause
  • Osteoporosis in men: epidemiology, pathophysiology, and clinical characterization
  • Falls as risk factors for fracture
  • Nonskeletal risk factors for osteoporosis and fractures
  • Outcomes following osteoporotic fractures
  • Skeletal heterogeneity and the purposes of bone remodeling: implications for the understanding of osteoporosis
  • On the evolution and contemporary roles of bone remodeling
  • Cytokines and the pathogenesis of osteoporosis
  • Animal models for osteoporosis
  • Bone and fat
  • Bone mineral acquisition in utero and during infancy and childhood
  • Bone acquisition in adolescence.
  • V: 2
  • Osteoporosis in childhood and adolescence
  • Osteoporosis associated with pregnancy
  • Osteoporosis in premenopausal women
  • Estrogen deficiency, postmenopausal osteoporosis, and age-related bone loss
  • Immobilization osteoporosis
  • Osteoporosis associated with illnesses and medications
  • Glucocorticoid-induced osteoporosis
  • Anticonvulsant-related bone disease
  • Thyroid hormone and the skeleton
  • The skeletal actions of parathyroid hormone in primary hyperparathyroidism and in osteoporosis
  • Osteogenesis imperfecta and other defects of bone development as occasional causes of adult osteoporosis
  • HIV and osteoporosis
  • Obesity, diabetes, and fractures
  • Osteoporosis in organ transplant patients
  • Osteoporosis associated with rheumatologic disorders
  • Osteoporosis associated with chronic kidney disease
  • Oral bone loss and systemic osteoporosis: weighing the risk benefit ratio of treatment
  • Cancer treatment-induced bone loss in patients with breast cancer: pathophysiology and clinical perspectives
  • Pathophysiology-prostate cancer
  • Mechanisms of bone destruction in myeloma
  • Evaluation of the patient at risk for osteoporosis
  • Imaging of osteoporosis
  • Osteoporosis: who should be treated? Who should be screened?
  • Clinical use of bone densitometry
  • Biochemical markers of bone turnover in osteoporosis
  • Fracture risk assessment: the development and application of FRAX®
  • Orthopedic aspects of osteoporosis
  • Falls prevention interventions
  • Physical therapy, physical modalities, and exercise regimens in the management of osteoporosis
  • Calcium in the treatment of osteoporosis
  • Vitamin D and its metabolities and analogs in the management of osteoporosis
  • Alternative therapy through nutrients and nutraceuticals
  • Design considerations for clinical investigations of osteoporosis
  • Lessons from bone histomorphometry on the mechanisms of action of osteoporosis drugs
  • Estrogen and estrogen analogs for prevention and treatment of osteoporosis
  • Androgens
  • Calcitonin in osteoporosis
  • Bisphosphonates: pharmacology and use in the treatment of osteoporosis
  • Osteonecrosis of the jaw and atypical femoral fractures
  • Condition critical: compliance and persistence with osteoporosis medications
  • Denosumab for the treatment of osteoporosis
  • Strontium ranelate in the prevention of osteoporotic fractures
  • Parathyroid hormone treatment for osteoporosis
  • New approaches to osteoporosis therapeutics
  • The past, present, and uncertain future of therapeutic innovation in osteoporosis.
Description
1 online resource (2 volumes (xxv, 1995 pages, 18 unnumbered pages of plates)) : illustrations (chiefly color)
Notes
  • Previous edition: 2008.
  • Includes bibliographical references and index.
Copyright Not EvaluatedCopyright Not Evaluated
Technical Details
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    a| V: 1 -- The bone organ system: form and function -- The nature of osteoporosis -- Reflections on osteoporosis -- Reflections on development of concepts of intercellular communication in bone -- Osteo-odyssey: a memoir -- Development of the skeleton -- The skeletal stem cell -- Osteoclast biology -- Osteoblast biology -- Osteocyte biology -- The regulatory role of matrix protein in mineralization of bone -- Parathyroid hormone and parathyroid hormone-related protein -- Vitamin D: biology, actions, and clinical implications -- Regulation of bone cell function by estrogens -- Androgens and skeletal biology: basic mechanisms -- Phosphatonins -- Skeletal growth factors -- Wnt signaling in skeletal homeostasis and diseases -- The mechanical behavior of bone -- Cellular and molecular mechanotransduction in bone -- Adaptation of skeletal structure to mechanical loading -- Biomechanics of hip and vertebral fractures -- Prevention of osteoporosis by physical signals: defining a potential role for nondrug strategies in the treatment of musculoskeletal injury and disease -- Epidemiologic methods in studies of osteoporosis -- Genetic determinants of osteoporosis -- Race, ethnicity, and osteoporosis -- Geographic variability in hip and vertebral fractures -- Nutrition and risk for osteoporosis -- Physical activity and exercise in the maintenance of the adult skeleton and the prevention of osteoporotic fractures -- Premenopausal reproductive and hormonal characteristics and the risk for osteoporosis -- Clinical and epidemiological studies: skeletal changes across menopause -- Osteoporosis in men: epidemiology, pathophysiology, and clinical characterization -- Falls as risk factors for fracture -- Nonskeletal risk factors for osteoporosis and fractures -- Outcomes following osteoporotic fractures -- Skeletal heterogeneity and the purposes of bone remodeling: implications for the understanding of osteoporosis -- On the evolution and contemporary roles of bone remodeling -- Cytokines and the pathogenesis of osteoporosis -- Animal models for osteoporosis -- Bone and fat -- Bone mineral acquisition in utero and during infancy and childhood -- Bone acquisition in adolescence.
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    a| Now in its third edition, Osteoporosis, is the most comprehensive, authoritative reference on this disease. Written by renowned experts in the field, this two-volume reference is a must-have for academic and medical libraries, physicians, researchers, and any company involved in osteoporosis research and development. Worldwide, 200 million women between 60-80 suffer from osteoporosis and have a lifetime risk of fracture between 30 and 40 % continuing to make osteoporosis a hot topic in medicine.
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