Item Details

Print View

Filaggrin: Basic Science, Epidemiology, Clinical Aspects and Management

edited by Jacob P. Thyssen, Howard Maibach
Format
EBook; Book; Online
Published
Heidelberg : Springer, [2014]
Language
English
ISBN
9783642543791, 3642543790, 3642543782, 9783642543784
Access Restriction
Electronic access is available for UVA students, faculty, staff, and affiliates only. IP address verification required.
Summary
Filaggrin proteins are expressed in several human tissues, including the skin, oral mucosa, conjunctivae, esophagus, cervix, and testes. While filaggrin guarantees both structural and functional normality of the human epidermis, its role in other tissues is largely unknown. Epidermal deficiency of filaggrin causes dry and scaly skin, but also strongly increases the risk of skin diseases, in particular ichthyosis vulgaris and atopic dermatitis. Importantly, the risk of related asthma, hay fever, and food allergy is also increased although filaggrin is not expressed in the airways and gastrointestinal tract. Common FLG mutations, leading to reduced filaggrin expression, have mainly been identified in Europeans and Asians, reaching a prevalence of 5-10%. Even in the absence of atopic dermatitis, the skin of individuals with FLG mutations differs fundamentally from normal skin, for example by generating more vitamin D and allowing chemicals and allergens to more widely penetrate across the stratum corneum. This textbook provides comprehensive and detailed coverage of the effects of filaggrin and filaggrin gene (FLG) mutations in health and disease (cutaneous and non-cutaneous) and also discusses the basic science, epidemiology, management, and future research areas. It will be of value to scientists and clinicians from different specialties.
Contents
  • Function of Filaggrin and Its Metabolites
  • Morphology of Filaggrin-Depleted Epidermis
  • Stratum Corneum Lipids and Filaggrin
  • Inflammatory-Driven Depletion of Filaggrin Proteins
  • Immune Activity and Vitamin D
  • Filaggrin-2
  • Animal Models
  • In Vitro Models of Filaggrin-Associated Diseases
  • Mapping Posttranslational Regulation of Filaggrin Using Phosphoproteomics
  • Noninvasive Detection of Filaggrin Molecules by Raman Spectroscopy
  • Filaggrin Genotyping
  • Prevalence of Filaggrin Gene Mutations: An Evolutionary Perspective
  • Filaggrin Gene Mutations in Asian Races
  • Filaggrin Gene Loss-of-Function Mutations and Exposure to Endocrine Disrupting Environmental Chemicals
  • Filaggrin Mutations and the Atopic March
  • Atopic Dermatitis
  • Asthma
  • Filaggrin Mutations, Skin Barrier Dysfunction, and Sensitization in Allergic Rhinitis
  • Filaggrin and Non-cutaneous Disease: Food Allergy
  • Filaggrin in Canine Skin
  • Ichthyosis Vulgaris and Other Disorders of Cornification
  • Xerosis Means "Dry Skin": Mechanisms, Skin Conditions, and Its Management
  • Allergic Contact Dermatitis
  • Irritant Contact Dermatitis
  • Hand Eczema
  • Filaggrin in Psoriasis
  • Filaggrin and Skin Infections
  • Atopic Dermatitis and Skin Cancer
  • Filaggrin Gene Mutations: A Clinician's Perspective
  • Filaggrin, the Skin Barrier, and Diabetes
  • The Eye and Filaggrin
  • Filaggrin Dysfunction and Its Association with Inflammatory Conditions of the GI Tract
  • Filaggrin, Human Papillomavirus, and the Cervix
  • Antibodies Against Citrullinated Proteins and Filaggrin
  • Filaggrin and the Oral Mucosa
  • Therapeutics and Other Interventions.
Description
1 online resource (xv, 373 pages) : illustrations (some color)
Notes
Includes bibliographical references and index.
Copyright Not EvaluatedCopyright Not Evaluated
Technical Details
  • Access in Virgo Classic
  • Staff View

    LEADER 05288cam a2200601Ki 4500
    001 u6372956
    003 SIRSI
    005 20140725133920.0
    006 m o d
    007 cr cnu---unuuu
    008 140611s2014 gw a ob 000 0 eng d
    019
      
      
    a| 880929676
    020
      
      
    a| 9783642543791 q| electronic bk.
    020
      
      
    a| 3642543790 q| electronic bk.
    020
      
      
    z| 3642543782
    020
      
      
    z| 9783642543784
    024
    7
      
    a| 10.1007/978-3-642-54379-1 2| doi
    035
      
      
    a| (OCoLC)881289646 z| (OCoLC)880929676
    049
      
      
    a| VAMM n| [Electronic Book/SPGR]
    040
      
      
    a| N$T b| eng e| rda e| pn c| N$T d| GW5XE d| YDXCP d| E7B
    050
      
    4
    a| RL793
    072
      
    7
    a| HEA x| 039000 2| bisacsh
    072
      
    7
    a| HEA x| 039130 2| bisacsh
    072
      
    7
    a| MED x| 014000 2| bisacsh
    072
      
    7
    a| MED x| 022000 2| bisacsh
    072
      
    7
    a| MED x| 112000 2| bisacsh
    072
      
    7
    a| MED x| 045000 2| bisacsh
    082
    0
    4
    a| 616.5/042 2| 23
    245
    0
    0
    a| Filaggrin : b| basic science, epidemiology, clinical aspects and management / c| edited by Jacob P. Thyssen, Howard Maibach.
    264
      
    1
    a| Heidelberg : b| Springer, c| [2014]
    300
      
      
    a| 1 online resource (xv, 373 pages) : b| illustrations (some color)
    336
      
      
    a| text b| txt 2| rdacontent
    337
      
      
    a| computer b| c 2| rdamedia
    338
      
      
    a| online resource b| cr 2| rdacarrier
    504
      
      
    a| Includes bibliographical references and index.
    505
    0
      
    a| Function of Filaggrin and Its Metabolites -- Morphology of Filaggrin-Depleted Epidermis -- Stratum Corneum Lipids and Filaggrin -- Inflammatory-Driven Depletion of Filaggrin Proteins -- Immune Activity and Vitamin D -- Filaggrin-2 -- Animal Models -- In Vitro Models of Filaggrin-Associated Diseases -- Mapping Posttranslational Regulation of Filaggrin Using Phosphoproteomics -- Noninvasive Detection of Filaggrin Molecules by Raman Spectroscopy -- Filaggrin Genotyping -- Prevalence of Filaggrin Gene Mutations: An Evolutionary Perspective -- Filaggrin Gene Mutations in Asian Races -- Filaggrin Gene Loss-of-Function Mutations and Exposure to Endocrine Disrupting Environmental Chemicals -- Filaggrin Mutations and the Atopic March -- Atopic Dermatitis -- Asthma -- Filaggrin Mutations, Skin Barrier Dysfunction, and Sensitization in Allergic Rhinitis -- Filaggrin and Non-cutaneous Disease: Food Allergy -- Filaggrin in Canine Skin -- Ichthyosis Vulgaris and Other Disorders of Cornification -- Xerosis Means "Dry Skin": Mechanisms, Skin Conditions, and Its Management -- Allergic Contact Dermatitis -- Irritant Contact Dermatitis -- Hand Eczema -- Filaggrin in Psoriasis -- Filaggrin and Skin Infections -- Atopic Dermatitis and Skin Cancer -- Filaggrin Gene Mutations: A Clinician's Perspective -- Filaggrin, the Skin Barrier, and Diabetes -- The Eye and Filaggrin -- Filaggrin Dysfunction and Its Association with Inflammatory Conditions of the GI Tract -- Filaggrin, Human Papillomavirus, and the Cervix -- Antibodies Against Citrullinated Proteins and Filaggrin -- Filaggrin and the Oral Mucosa -- Therapeutics and Other Interventions.
    506
      
      
    a| Electronic access is available for UVA students, faculty, staff, and affiliates only. IP address verification required.
    520
      
      
    a| Filaggrin proteins are expressed in several human tissues, including the skin, oral mucosa, conjunctivae, esophagus, cervix, and testes. While filaggrin guarantees both structural and functional normality of the human epidermis, its role in other tissues is largely unknown. Epidermal deficiency of filaggrin causes dry and scaly skin, but also strongly increases the risk of skin diseases, in particular ichthyosis vulgaris and atopic dermatitis. Importantly, the risk of related asthma, hay fever, and food allergy is also increased although filaggrin is not expressed in the airways and gastrointestinal tract. Common FLG mutations, leading to reduced filaggrin expression, have mainly been identified in Europeans and Asians, reaching a prevalence of 5-10%. Even in the absence of atopic dermatitis, the skin of individuals with FLG mutations differs fundamentally from normal skin, for example by generating more vitamin D and allowing chemicals and allergens to more widely penetrate across the stratum corneum. This textbook provides comprehensive and detailed coverage of the effects of filaggrin and filaggrin gene (FLG) mutations in health and disease (cutaneous and non-cutaneous) and also discusses the basic science, epidemiology, management, and future research areas. It will be of value to scientists and clinicians from different specialties.
    650
      
    0
    a| Skin x| Diseases x| Genetic aspects.
    650
      
    0
    a| Medical genetics.
    655
      
    7
    a| Electronic books. 2| local
    700
    1
      
    a| Thyssen, Jacob P., e| editors.
    700
    1
      
    a| Maibach, Howard I., e| editors.
    776
    0
    8
    i| Print version: t| Filaggrin. Thyssen, epidemiology, clinical aspects and management z| 3642543782 w| (OCoLC)880132168
    856
    4
    0
    u| http://proxy01.its.virginia.edu/login?url=http://dx.doi.org/10.1007/978-3-642-54379-1
    994
      
      
    a| 92 b| VAM
    596
      
      
    a| 19
    999
      
      
    a| XX(6372956.1) ELECTRONIC w| HS-LC i| 6372956-1001 l| INTERNET m| HEALTHSCI t| E-BOOK
▾See more
▴See less

Availability

Google Preview

Google Books Preview

Read Online