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Transduction Mechanisms in Cellular Signaling [electronic resource]

editors-in-chief, Edward A. Dennis, Ralph A. Bradshaw
Format
EBook; Book; Online
Published
Amsterdam ; Boston : Elsevier/AP, 2011.
Edition
1st ed
Language
English
ISBN
9780123838636, 0123838630, 9780123838629, 0123838622
Access Restriction
Electronic access is available for UVA students, faculty, staff, and affiliates only. IP address verification required.
Summary
"Cell signaling, which is also often referred to as signal transduction or, in more specialized cases, transmembrane signaling, is the process by which cells communicate with their environment and respond temporally to external cues that they sense there. All cells have the capacity to achieve this to some degree, albeit with a wide variation in purpose, mechanism, and response. At the same time, there is a remarkable degree of similarity over quite a range of species, particularly in the eukaryotic kingdom, and comparative physiology has been a useful tool in the development of this field. The central importance of this general phenomenon (sensing of external stimuli by cells) has been appreciated for a long time, but it has truly become a dominant part of cell and molecular biology research in the past three decades, in part because a description of the dynamic responses of cells to external stimuli is, in essence, a description of the life process itself. This approach lies at the core of the developing fields of proteomics and metabolomics, and its importance to human and animal health is already plainly evident"--Provided by publisher.
Contents
  • Intracellular Signaling
  • Eukaryotic Kinomes: Genomics and Evolution of Protein Kinases
  • Modular Protein Interaction Domains in Cellular Communication
  • Recognition of Phospho-Serine/Threonine Phosphorylated Proteins by Phospho-Serine/Threonine-Binding Domains
  • Protein Kinase Inhibitors
  • Principles of Kinase Regulation
  • Mammalian MAP Kinases
  • The Negative Regulation of JAK/STAT Signaling
  • Protein Proximity Interactions
  • Global Analysis of Phosphoregulatory Networks
  • Phosphatase Families Dephosphorylating Serine and Threonine Residues in Proteins
  • The Structure and Topology of Protein Serine/Threonine Phosphatases
  • SH2 Domain-Containing Protein-Tyrosine Phosphatases
  • Calcineurin
  • Protein Serine/Threonine-Phosphatase ₂C (PP₂C)
  • Inhibitors of Protein Tyrosine Phosphatases
  • MAP Kinase Phosphatases
  • Protein Phosphatase ₂A
  • Lipid-Mediated Localization of Signaling proteins
  • Structural Principles of Lipid Second Messenger Recognition
  • Pleckstrin Homology (PH) Domains
  • PX Domains
  • FYVE Domains in Membrane Trafficking and Cell Signaling
  • Type I Phosphatidylinositol ₄-Phosphate ₅-Kinases (PI₄P ₅-kinases)
  • Phosphoinositide ₃-Kinases
  • Inositol Pentakisphosphate: A Signal Transduction Hub
  • IP₃ Receptors
  • PTEN
  • PTEN/MTM Phosphatidylinositol Phosphatases
  • Diacylglycerol Kinases
  • Phospholipase C
  • Phospholipase D
  • Role of Phospholipase A₂ Forms in Arachidonic Acid Mobilization and Eicosanoid Generation
  • Prostaglandin Mediators
  • Leukotriene Mediators
  • Sphingosine-₁-Phosphate Receptors: An Update
  • Adenylyl Cyclases
  • Phosphodiesterase Families
  • cAMP-Dependent Protein Kinase
  • Cyclic GMP-Dependent Protein Kinase: Targeting and Control of Expression
  • Substrates of Cyclic Nucleotide-Dependent Protein Kinases
  • Physiological Substrates of PKA and PKG
  • Inhibitors of Cyclic AMP- and Cyclic GMP-Dependent Protein Kinases
  • AKAP Transduction Units: Context dependent Assembly of Signaling Complexes
  • Cyclic Nucleotide Specificity and Cross-Activation of Cyclic Nucleotide Receptors
  • Signal Transduction by G Proteins: Basic Principles, Molecular Diversity, and Structural Basis of Their Actions
  • G-Protein-Coupled Receptors, Signal Fidelity, and Cell Transformation
  • Regulation of G Proteins by Covalent Modification
  • Signaling Through Gz
  • Mono-ADP-Ribosylation of Heterotrimeric G Proteins
  • Specificity of G-Protein ß y Dimer Signaling
  • Reversible Palmitoylation in G Protein Signaling
  • The Influence of Intracellular Location on Function of Ras Proteins
  • Role of R-Ras in Cell Growth
  • The Ran GTPase: Cellular Roles and Regulation
  • Cdc42 and Its Cellular Functions
  • Structure of Rho Family Targets.
Description
1 online resource (xvi, 586 pages) : illustrations (some color)
Notes
Includes bibliographical references and index.
Technical Details
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