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Intercellular Signaling in Development and Disease [electronic resource]

editors-in-chief, Edward A. Dennis, Ralph A. Bradshaw
Format
EBook; Book; Online
Published
Amsterdam ; Boston : Academic Press, 2011.
Language
English
ISBN
9780123822161, 0123822165, 9780123822154, 0123822157
Access Restriction
Electronic access is available for UVA students, faculty, staff, and affiliates only. IP address verification required.
Summary
"Cell signaling, which is also often referred to as signal transduction or, in more specialized cases, transmembrane signaling, is the process by which cells communicate with their environment and respond temporally to external cues that they sense there. All cells have the capacity to achieve this to some degree, albeit with a wide variation in purpose, mechanism, and response. At the same time, there is a remarkable degree of similarity over quite a range of species, particularly in the eukaryotic kingdom, and comparative physiology has been a useful tool in the development of this field. The central importance of this general phenomenon (sensing of external stimuli by cells) has been appreciated for a long time, but it has truly become a dominant part of cell and molecular biology research in the past three decades, in part because a description of the dynamic responses of cells to external stimuli is, in essence, a description of the life process itself. This approach lies at the core of the developing fields of proteomics and metabolomics, and its importance to human and animal health is already plainly evident"--Provided by publisher.
Contents
  • Signaling in Development and Disease
  • Overview of Cell-Cell and Cell-Matrix Interactions
  • Integrin Signaling: Cell Migration, Proliferation, and Survival
  • The Focal Adhesion: A Network of Molecular Interactions
  • Cadherin Regulation of Adhesive Interactions
  • In vivo Functions of Heterotrimeric G Proteins
  • G-Protein Signaling in Chemotaxis
  • Interactive Signaling Pathways in the Vasculature
  • Signaling Pathways Involved in Cardiogenesis
  • Calcium Signaling in Cardiac Muscle
  • Calcium Signaling in Smooth Muscle
  • Trophic Effects of Gut Hormones in the Gastrointestinal Tract
  • Cell-Cell and Cell-Matrix Interactions in Bone
  • Cell-Cell Signaling in the Testis and Ovary
  • Kidney
  • Cytokines and Cytokine Receptors Regulating Cell Survival, Proliferation, and Differentiation in Hematopoiesis
  • CD45
  • Signal Transduction in T Lymphocytes
  • Signal Transduction via the B Cell Antigen Receptor: A Crucial Regulator of B Cell Biology
  • Signaling Pathways Regulating Growth and Differentiation of Adult Stem Cells
  • Wnt Signaling in Development
  • Interactions between Wnt/ß-Catenin/Fgf and Chemokine Signaling in Lateral Line Morphogenesis
  • Integration of BMP, RTK, and Wnt Signaling Through Smad1 Phosphorylations
  • Hedgehog Signaling in Development and Disease
  • Regulation of Vertebrate Left-Right Axis Development by Calcium
  • LIN-12/Notch Signaling: Induction, Lateral Specification, and Interaction with the EGF/Ras Pathway
  • Proteolytic Activation of Notch Signaling: Roles for Ligand Endocytosis and Mechanotransduction
  • Vascular Endothelial Growth Factors and Receptors: Signaling in Vascular Development
  • BMPs in Development
  • Signaling from Fibroblast Growth Factor Receptors in Development and Disease
  • Regulation of Synaptic Fusion by Heterotrimeric G Proteins
  • The Role of Receptor Protein Tyrosine Phosphatases in Axonal Pathfinding
  • Neurotrophin Signaling in Development
  • Attractive and Repulsive Signaling in Nerve Growth Cone Navigation
  • Semaphorins and their Receptors in Vertebrates and Invertebrates
  • Signaling Pathways that Regulate Cell Fate in the Embryonic Spinal Cord
  • Ras and Cancer
  • Targeting Ras for Anticancer Drug Discovery
  • The Roles of Ras Family Small GTPases in Breast Cancer
  • Signaling Pathways in the Normal and Neoplastic Breast
  • Aberrant Signaling Pathways in Pancreatic Cancer: Opportunities for Targeted Therapeutics
  • Regulatory Signaling in Pancreatic Organogenesis: Implications for Aberrant Signaling in Pancreatic Cancer
  • Angiogenesis Signaling Pathways as Targets in Cancer Therapy
  • Clinical Applications of Kinase Inhibitors in Solid Tumors
  • Adipokine Signaling: Implications for Obesity
  • CXC Chemokine Signaling in Interstitial Lung Diseases
  • ER and Oxidative Stress: Implications in Disease
  • Protein Serine/Threonine Phosphatase Inhibitors and Human Disease
  • Signal Transduction in Rheumatoid Arthritis and Systemic Lupus Erythematosus
  • Translational Concepts in Vasculitis
  • Translational Implications of Proteomics
  • Translational Implications of MicroRNAs in Clinical Diagnostics and Therapeutics.
Description
1 online resource (xvi, 532 pages) : illustrations (some color)
Notes
Includes bibliographical references and index.
Technical Details
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