Item Details

Handbook of Statistical Genetics

edited by D.J. Balding, M. Bishop, C. Cannings
Format
Book
Published
Chichester ; New York : Wiley, c2001.
Language
English
ISBN
0471860948 (alk. paper)
Contents
  • Part 1 Bioinformatics 1
  • 1 Chromosome Maps / T.P. Speed, H. Zhao 3
  • 1.2 Genetic Maps 5
  • 1.3 Physical Maps 20
  • 1.4 Radiation Hybrid Mapping 27
  • 1.5 Other Physical Mapping Approaches 31
  • 1.6 Gene Maps 31
  • 1.7 Programs for Physical Mapping 31
  • 2 Statistical Significance in Biological Sequence Comparison / W.R. Pearson, T.C. Wood 39
  • 2.2 Statistical Significance and Biological Significance 40
  • 2.3 Estimating Statistical Significance for Local Similarity Searches 43
  • 2.4 Summary: Exploiting Statistical Estimates 61
  • 3 Probabilistic Models for the Study of Protein Evolution / J.L. Thorne, N. Goldman 67
  • 3.2 Dayhoff Model 68
  • 3.3 Amino Acid Composition 70
  • 3.4 Heterogeneity of Replacement Rates Among Sites 71
  • 3.5 Protein Structure 72
  • 3.6 Variation of Preferred Residues Among Sites 74
  • 3.7 Models with a Physicochemical Basis 75
  • 3.8 Codon-Based Models 76
  • 3.9 Covariation Among Sites 77
  • 4 Statistical Approaches in Eukaryotic Gene Prediction / V. Solovyev 83
  • 4.1 Structural Organization and Expression of Eukaryotic Genes 83
  • 4.2 Methods of Functional Signal Recognition 86
  • 4.3 Performance Measures 89
  • 4.4 Linear Discriminant Analysis 90
  • 4.5 Prediction of Donor and Acceptor Splice Junctions 91
  • 4.6 Identification of Promoter Regions in Human DNA 99
  • 4.7 Recognition of Polya Signals 105
  • 4.8 Characteristics for Recognition of 3'-Processing Sites 106
  • 4.9 Identification of Multiple Genes in Genomic Sequences 107
  • 4.10 Discriminative and Probabilistic Approaches to Multiple Gene Prediction 108
  • 4.11 Internal Exon Recognition 111
  • 4.12 Recognition of Flanking Exons 112
  • 4.13 Performance of Gene Identification Programs 114
  • 4.14 Using Protein Similarity Information to Improve Gene Prediction 116
  • 4.15 Annotation of Sequences from Genome Sequencing Projects 117
  • 4.16 Infogene: A Gene-Centered Database of Known and Predicted Genes 119
  • 5 Protein Structure / W.R. Taylor 129
  • 5.2 Basic Principles 130
  • 5.3 Structure Comparison and Classification 133
  • 5.4 Protein Structure Prediction 143
  • Part 2 Population Genetics 151
  • 6 Mathematical Models in Population Genetics / C. Neuhauser 153
  • 6.1 A Brief History of the Role of Selection 153
  • 6.2 Mutation, Random Genetic Drift, and Selection 154
  • 6.3 Diffusion Approximation 158
  • 6.4 Infinite Allele Model 163
  • 6.5 Other Models of Mutation and Selection 166
  • 6.6 Coalescent Theory 167
  • 6.7 Detecting Selection 173
  • 7 Coalescent Theory / M. Nordborg 179
  • 7.2 Coalescent 180
  • 7.3 Generalizing the Coalescent 186
  • 7.4 Geographical Structure 190
  • 7.5 Segregation 192
  • 7.6 Recombination 195
  • 7.7 Selection 200
  • 7.8 Neutral Mutations 205
  • 8 Inference Under the Coalescent / M. Stephens 213
  • 8.2 Likelihood and the Coalescent 218
  • 8.3 Importance Sampling 220
  • 8.4 Markov Chain Monte Carlo 224
  • 9 Inferences from Spatial Population Genetics / F. Rousset 239
  • 9.2 Models in Spatial Population Genetics 241
  • 9.3 Methods of Inference 243
  • 9.4 Inference Under the Different Models 249
  • 9.5 Spatial Analyses in Practice 256
  • 9.6 Software 258
  • Appendix A Analysis of Variance and Probabilities of Identity 259
  • Appendix B Likelihood Analysis of the Island Model 263
  • 10 Analysis of Population Subdivision / L. Excoffier 271
  • 10.2 Fixation Index F 272
  • 10.3 Wright's F-Statistics in Hierarchic Subdivisions 274
  • 10.4 Analysis of Genetic Subdivision Under an Analysis of Variance Framework 279
  • 10.5 Relationship Between Different Definitions of Fixation Indexes 287
  • 10.6 F-Statistics and Coalescence Times 290
  • 10.7 Analysis of Molecular Data: The Amova Framework 291
  • 10.8 Significance Testing 299
  • 10.9 Related and Remaining Problems 301
  • - 11 Linkage Disequilibrium and Recombination / R.R. Hudson 309
  • 11.2 Tests of Association 311
  • 11.3 Properties of Linkage Disequilibrium Under Population Genetic Models 318
  • Part 3 Evolutionary Genetics 325
  • 12 Adaptive Molecular Evolution / Z. Yang 327
  • 12.2 Markov Model of Codon Substitution 329
  • 12.3 Estimation of Synonymous and Non-Synonymous Substitution Rates Between Two Sequences 331
  • 12.4 Likelihood Calculation on a Phylogeny 338
  • 12.5 Detecting Adaptive Evolution Along Lineages 339
  • 12.6 Inferring Amino Acid Sites Under Diversifying Selection 343
  • 12.7 Limitations of Current Methods 347
  • 12.8 Computer Software 348
  • 13 Genome Evolution / J.F.Y. Brookfield 351
  • 13.2 Structure and Function of Genomes 353
  • 13.3 Organization of Genomes 359
  • 13.4 Population Genetics and the Genome 364
  • 13.5 Population Genetics of Mobile DNAs 366
  • 14 Virus Evolution / Y. Suzuki, A. Wyndham, T. Gojobori 377
  • 14.1 Introduction: HIV as a Model for Virus Evolution 377
  • 14.3 Evolutionary Rate 380
  • 14.4 Natural Selection 387
  • 14.5 Phylogenetic Relationships Between HIV and SIV Members 390
  • 14.6 Recombination 392
  • 14.7 Molecular Clock and Divergence Dates 394
  • 14.8 Population Dynamics and Models 397
  • 15 Application of the Likelihood Function in Phylogenetic Analysis / J.P. Huelsenbeck, J.P. Bollback 415
  • 15.2 History 417
  • 15.3 Likelihood Function 418
  • 15.4 Developing an Intuition of Likelihood 424
  • 15.5 Method of Maximum Likelihood 426
  • 15.6 Bayesian Inference 429
  • 15.7 Markov Chain Monte Carlo 431
  • 15.8 Assessing Uncertainty of Phylogenies 435
  • 15.9 Hypothesis Testing and Model Choice 436
  • 15.10 Comparative Analysis 437
  • 16 Phylogenetics: Parsimony and Distance Methods / D. Penny, M. Hendy 445
  • 16.3 Theoretical Background 456
  • 16.4 Methods for Inferring Evolutionary Trees 466
  • 16.5 Search Strategies 478
  • Part 4 Genetic Epidemiology 485
  • 17 Nonparametric Linkage / P. Holmans 487
  • 17.2 Pros and Cons of Model-Free Methods 488
  • 17.3 Model-Free Methods for Dichotomous Traits 489
  • 17.4 Model-Free Methods for Quantitative Traits 498
  • 18 Transmission/Disequilibrium Test / W.J. Ewens, R.S. Spielman 507
  • 18.2 Case-Control Test 508
  • 18.3 Transmission/Disequilibrium Test 509
  • 18.4 Statistical Properties of the TDT 510
  • 18.5 TDT as a Test of Association 512
  • 18.6 Generalizations of the TDT: More than Two Marker Alleles 513
  • 18.7 Generalizations of the TDT: Unaffected Sibs 514
  • 18.8 S-TDT Used as a Test of Association 517
  • 19 Population Association / D. Clayton 519
  • 19.2 Measures of Association 520
  • 19.3 Case-Control Studies 522
  • 19.4 Tests for Association 524
  • 19.5 Logistic Regression and Log-Linear Models 527
  • 19.6 Stratification and Matching 529
  • 19.7 Unmeasured Confounding 532
  • 19.8 Multiple Alleles 534
  • 19.9 Haplotype Analysis 537
  • 20 Linkage Analysis / E.A. Thompson 541
  • 20.2 Early Years 542
  • 20.3 Development of Human Genetic Linkage Analysis 544
  • 20.4 Pedigree Years: Segregation and Linkage Analysis 546
  • 20.5 Likelihood and Location Score Computation 548
  • 20.6 Linkage Analysis of Complex Traits 553
  • 20.7 Map Estimation, Map Uncertainty, and the Meiosis Model 556
  • 20.8 Future 559
  • Part 5 Animal and Plant Breeding 565
  • 21 Quantitative Trait Loci in Inbred Lines / R.C. Jansen 567
  • 21.2 Segregation Analysis 570
  • 21.3 Dissecting Quantitative Variation with the Aid of Molecular Markers 575
  • 21.4 QTL Detection Strategies 585
  • 22 Mapping Quantitative Trait Loci in Outbred Pedigrees / I. Hoeschele 599
  • 22.2 Linkage Mapping via Least Squares or Maximum Likelihood and Fixed Effects Models 601
  • 22.3 Linkage Mapping via Residual Maximum Likelihood and Random Effects Models 605-
  • 22.4 Linkage Mapping via Bayesian Methodology 614
  • 22.5 Genotype Sampling in Complex Pedigrees 625
  • 22.6 Fine Mapping of Quantitative Trait Loci 636
  • 23 Inferences About Breeding Values / D. Gianola 645
  • 23.2 Landmarks 646
  • 23.3 Future Developments 664
  • 24 Marker-Assisted Selection and Introgression / J.C. Whittaker 673
  • 24.2 Marker-Assisted Selection: Inbred Line Crosses 674
  • 24.3 Marker-Assisted Selection: Outbred Populations 681
  • 24.4 Marker-Assisted Introgression 686
  • Part 6 Applications 695
  • 25 Ethics in the Use of Statistics in Genetics / D. Beyleveld 697
  • 25.2 What is Ethics? 698
  • 25.3 Normative Moral Theories and Institutionalized Consensus 700
  • 25.4 Uses of Statistics 709
  • 26 Forensics / B.S. Weir 721
  • 26.2 Principles of Interpretation 722
  • 26.3 Profile Probabilities 724
  • 26.4 Mixtures 730
  • 26.5 Sampling Issues 733
  • 26.6 Other Forensic Issues 735
  • 27 Pharmacogenetics / N.J. Schork, D. Fallin, H.K. Tiwari, M.A. Schork 741
  • 27.1 Introduction: The Scope of Pharmacogenetics 742
  • 27.2 General Issues in the Pharmacogenetic Analysis of Clinical Trials 743
  • 27.3 Phenotypic and Outcome Assessment via Mixture Distribution Analysis 746
  • 27.4 Optimal Genotyping Protocols via Extreme Sampling 749
  • 27.5 Multilocus and Haplotype Analysis 752
  • 27.6 Assessing Sample Homogeneity 755
  • 27.7 Sequential Pharmacogenetic Designs 757
  • 28 Statistical Basis of Risk Calculations / R. Chakraborty 765
  • 28.2 Concept of Risk in the Formulation of Bayesian Inference 766
  • 28.3 Various Stages of Risk Estimation 767
  • 28.4 Major Advances in Estimating the Conditional Probability 768
  • 28.5 Use of Genetic Data in Other Types of Risk Estimation 772
  • 29 Conservation Genetics / M.A. Beaumont 779
  • -- 29.2 Estimating Effective Population Size 780
  • 29.3 Hybridization 798
  • 30 Genetic History of the Human Species / J.H. Relethford 813
  • 30.2 Models of Modern Human Origins 814
  • 30.3 Gene Trees 818
  • 30.4 African Genetic Diversity 824
  • 30.5 Genetic Distances Between Living Human Populations 828
  • 30.6 Genetic Demography of the Human Species 832.
Description
xxvi, 863 p. : ill. ; 26 cm.
Notes
Includes bibliographical references and index.
Local Notes
HEALTH SCIENCES: Purchased with support from the Ralph Erskine Conrad Memorial Fund.
Technical Details
  • Access in Virgo Classic

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    a| Handbook of statistical genetics / c| edited by D.J. Balding, M. Bishop, C. Cannings.
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    a| Chichester ; a| New York : b| Wiley, c| c2001.
    300
      
      
    a| xxvi, 863 p. : b| ill. ; c| 26 cm.
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    g| Part 1 t| Bioinformatics g| 1 -- g| 1 t| Chromosome Maps / r| T.P. Speed, H. Zhao g| 3 -- g| 1.2 t| Genetic Maps g| 5 -- g| 1.3 t| Physical Maps g| 20 -- g| 1.4 t| Radiation Hybrid Mapping g| 27 -- g| 1.5 t| Other Physical Mapping Approaches g| 31 -- g| 1.6 t| Gene Maps g| 31 -- g| 1.7 t| Programs for Physical Mapping g| 31 -- g| 2 t| Statistical Significance in Biological Sequence Comparison / r| W.R. Pearson, T.C. Wood g| 39 -- g| 2.2 t| Statistical Significance and Biological Significance g| 40 -- g| 2.3 t| Estimating Statistical Significance for Local Similarity Searches g| 43 -- g| 2.4 t| Summary: Exploiting Statistical Estimates g| 61 -- g| 3 t| Probabilistic Models for the Study of Protein Evolution / r| J.L. Thorne, N. Goldman g| 67 -- g| 3.2 t| Dayhoff Model g| 68 -- g| 3.3 t| Amino Acid Composition g| 70 -- g| 3.4 t| Heterogeneity of Replacement Rates Among Sites g| 71 -- g| 3.5 t| Protein Structure g| 72 -- g| 3.6 t| Variation of Preferred Residues Among Sites g| 74 -- g| 3.7 t| Models with a Physicochemical Basis g| 75 -- g| 3.8 t| Codon-Based Models g| 76 -- g| 3.9 t| Covariation Among Sites g| 77 -- g| 4 t| Statistical Approaches in Eukaryotic Gene Prediction / r| V. Solovyev g| 83 -- g| 4.1 t| Structural Organization and Expression of Eukaryotic Genes g| 83 -- g| 4.2 t| Methods of Functional Signal Recognition g| 86 -- g| 4.3 t| Performance Measures g| 89 -- g| 4.4 t| Linear Discriminant Analysis g| 90 -- g| 4.5 t| Prediction of Donor and Acceptor Splice Junctions g| 91 -- g| 4.6 t| Identification of Promoter Regions in Human DNA g| 99 -- g| 4.7 t| Recognition of Polya Signals g| 105 -- g| 4.8 t| Characteristics for Recognition of 3'-Processing Sites g| 106 -- g| 4.9 t| Identification of Multiple Genes in Genomic Sequences g| 107 -- g| 4.10 t| Discriminative and Probabilistic Approaches to Multiple Gene Prediction g| 108 -- g| 4.11 t| Internal Exon Recognition g| 111 -- g| 4.12 t| Recognition of Flanking Exons g| 112 -- g| 4.13 t| Performance of Gene Identification Programs g| 114 -- g| 4.14 t| Using Protein Similarity Information to Improve Gene Prediction g| 116 -- g| 4.15 t| Annotation of Sequences from Genome Sequencing Projects g| 117 -- g| 4.16 t| Infogene: A Gene-Centered Database of Known and Predicted Genes g| 119 -- g| 5 t| Protein Structure / r| W.R. Taylor g| 129 -- g| 5.2 t| Basic Principles g| 130 -- g| 5.3 t| Structure Comparison and Classification g| 133 -- g| 5.4 t| Protein Structure Prediction g| 143 -- g| Part 2 t| Population Genetics g| 151 -- g| 6 t| Mathematical Models in Population Genetics / r| C. Neuhauser g| 153 -- g| 6.1 t| A Brief History of the Role of Selection g| 153 -- g| 6.2 t| Mutation, Random Genetic Drift, and Selection g| 154 -- g| 6.3 t| Diffusion Approximation g| 158 -- g| 6.4 t| Infinite Allele Model g| 163 -- g| 6.5 t| Other Models of Mutation and Selection g| 166 -- g| 6.6 t| Coalescent Theory g| 167 -- g| 6.7 t| Detecting Selection g| 173 -- g| 7 t| Coalescent Theory / r| M. Nordborg g| 179 -- g| 7.2 t| Coalescent g| 180 -- g| 7.3 t| Generalizing the Coalescent g| 186 -- g| 7.4 t| Geographical Structure g| 190 -- g| 7.5 t| Segregation g| 192 -- g| 7.6 t| Recombination g| 195 -- g| 7.7 t| Selection g| 200 -- g| 7.8 t| Neutral Mutations g| 205 -- g| 8 t| Inference Under the Coalescent / r| M. Stephens g| 213 -- g| 8.2 t| Likelihood and the Coalescent g| 218 -- g| 8.3 t| Importance Sampling g| 220 -- g| 8.4 t| Markov Chain Monte Carlo g| 224 -- g| 9 t| Inferences from Spatial Population Genetics / r| F. Rousset g| 239 -- g| 9.2 t| Models in Spatial Population Genetics g| 241 -- g| 9.3 t| Methods of Inference g| 243 -- g| 9.4 t| Inference Under the Different Models g| 249 -- g| 9.5 t| Spatial Analyses in Practice g| 256 -- g| 9.6 t| Software g| 258 -- g| Appendix A t| Analysis of Variance and Probabilities of Identity g| 259 -- g| Appendix B t| Likelihood Analysis of the Island Model g| 263 -- g| 10 t| Analysis of Population Subdivision / r| L. Excoffier g| 271 -- g| 10.2 t| Fixation Index F g| 272 -- g| 10.3 t| Wright's F-Statistics in Hierarchic Subdivisions g| 274 -- g| 10.4 t| Analysis of Genetic Subdivision Under an Analysis of Variance Framework g| 279 -- g| 10.5 t| Relationship Between Different Definitions of Fixation Indexes g| 287 -- g| 10.6 t| F-Statistics and Coalescence Times g| 290 -- g| 10.7 t| Analysis of Molecular Data: The Amova Framework g| 291 -- g| 10.8 t| Significance Testing g| 299 -- g| 10.9 t| Related and Remaining Problems g| 301 --- g| 11 t| Linkage Disequilibrium and Recombination / r| R.R. Hudson g| 309 -- g| 11.2 t| Tests of Association g| 311 -- g| 11.3 t| Properties of Linkage Disequilibrium Under Population Genetic Models g| 318 -- g| Part 3 t| Evolutionary Genetics g| 325 -- g| 12 t| Adaptive Molecular Evolution / r| Z. Yang g| 327 -- g| 12.2 t| Markov Model of Codon Substitution g| 329 -- g| 12.3 t| Estimation of Synonymous and Non-Synonymous Substitution Rates Between Two Sequences g| 331 -- g| 12.4 t| Likelihood Calculation on a Phylogeny g| 338 -- g| 12.5 t| Detecting Adaptive Evolution Along Lineages g| 339 -- g| 12.6 t| Inferring Amino Acid Sites Under Diversifying Selection g| 343 -- g| 12.7 t| Limitations of Current Methods g| 347 -- g| 12.8 t| Computer Software g| 348 -- g| 13 t| Genome Evolution / r| J.F.Y. Brookfield g| 351 -- g| 13.2 t| Structure and Function of Genomes g| 353 -- g| 13.3 t| Organization of Genomes g| 359 -- g| 13.4 t| Population Genetics and the Genome g| 364 -- g| 13.5 t| Population Genetics of Mobile DNAs g| 366 -- g| 14 t| Virus Evolution / r| Y. Suzuki, A. Wyndham, T. Gojobori g| 377 -- g| 14.1 t| Introduction: HIV as a Model for Virus Evolution g| 377 -- g| 14.3 t| Evolutionary Rate g| 380 -- g| 14.4 t| Natural Selection g| 387 -- g| 14.5 t| Phylogenetic Relationships Between HIV and SIV Members g| 390 -- g| 14.6 t| Recombination g| 392 -- g| 14.7 t| Molecular Clock and Divergence Dates g| 394 -- g| 14.8 t| Population Dynamics and Models g| 397 -- g| 15 t| Application of the Likelihood Function in Phylogenetic Analysis / r| J.P. Huelsenbeck, J.P. Bollback g| 415 -- g| 15.2 t| History g| 417 -- g| 15.3 t| Likelihood Function g| 418 -- g| 15.4 t| Developing an Intuition of Likelihood g| 424 -- g| 15.5 t| Method of Maximum Likelihood g| 426 -- g| 15.6 t| Bayesian Inference g| 429 -- g| 15.7 t| Markov Chain Monte Carlo g| 431 -- g| 15.8 t| Assessing Uncertainty of Phylogenies g| 435 -- g| 15.9 t| Hypothesis Testing and Model Choice g| 436 -- g| 15.10 t| Comparative Analysis g| 437 -- g| 16 t| Phylogenetics: Parsimony and Distance Methods / r| D. Penny, M. Hendy g| 445 -- g| 16.3 t| Theoretical Background g| 456 -- g| 16.4 t| Methods for Inferring Evolutionary Trees g| 466 -- g| 16.5 t| Search Strategies g| 478 -- g| Part 4 t| Genetic Epidemiology g| 485 -- g| 17 t| Nonparametric Linkage / r| P. Holmans g| 487 -- g| 17.2 t| Pros and Cons of Model-Free Methods g| 488 -- g| 17.3 t| Model-Free Methods for Dichotomous Traits g| 489 -- g| 17.4 t| Model-Free Methods for Quantitative Traits g| 498 -- g| 18 t| Transmission/Disequilibrium Test / r| W.J. Ewens, R.S. Spielman g| 507 -- g| 18.2 t| Case-Control Test g| 508 -- g| 18.3 t| Transmission/Disequilibrium Test g| 509 -- g| 18.4 t| Statistical Properties of the TDT g| 510 -- g| 18.5 t| TDT as a Test of Association g| 512 -- g| 18.6 t| Generalizations of the TDT: More than Two Marker Alleles g| 513 -- g| 18.7 t| Generalizations of the TDT: Unaffected Sibs g| 514 -- g| 18.8 t| S-TDT Used as a Test of Association g| 517 -- g| 19 t| Population Association / r| D. Clayton g| 519 -- g| 19.2 t| Measures of Association g| 520 -- g| 19.3 t| Case-Control Studies g| 522 -- g| 19.4 t| Tests for Association g| 524 -- g| 19.5 t| Logistic Regression and Log-Linear Models g| 527 -- g| 19.6 t| Stratification and Matching g| 529 -- g| 19.7 t| Unmeasured Confounding g| 532 -- g| 19.8 t| Multiple Alleles g| 534 -- g| 19.9 t| Haplotype Analysis g| 537 -- g| 20 t| Linkage Analysis / r| E.A. Thompson g| 541 -- g| 20.2 t| Early Years g| 542 -- g| 20.3 t| Development of Human Genetic Linkage Analysis g| 544 -- g| 20.4 t| Pedigree Years: Segregation and Linkage Analysis g| 546 -- g| 20.5 t| Likelihood and Location Score Computation g| 548 -- g| 20.6 t| Linkage Analysis of Complex Traits g| 553 -- g| 20.7 t| Map Estimation, Map Uncertainty, and the Meiosis Model g| 556 -- g| 20.8 t| Future g| 559 -- g| Part 5 t| Animal and Plant Breeding g| 565 -- g| 21 t| Quantitative Trait Loci in Inbred Lines / r| R.C. Jansen g| 567 -- g| 21.2 t| Segregation Analysis g| 570 -- g| 21.3 t| Dissecting Quantitative Variation with the Aid of Molecular Markers g| 575 -- g| 21.4 t| QTL Detection Strategies g| 585 -- g| 22 t| Mapping Quantitative Trait Loci in Outbred Pedigrees / r| I. Hoeschele g| 599 -- g| 22.2 t| Linkage Mapping via Least Squares or Maximum Likelihood and Fixed Effects Models g| 601 -- g| 22.3 t| Linkage Mapping via Residual Maximum Likelihood and Random Effects Models g| 605- -- g| 22.4 t| Linkage Mapping via Bayesian Methodology g| 614 -- g| 22.5 t| Genotype Sampling in Complex Pedigrees g| 625 -- g| 22.6 t| Fine Mapping of Quantitative Trait Loci g| 636 -- g| 23 t| Inferences About Breeding Values / r| D. Gianola g| 645 -- g| 23.2 t| Landmarks g| 646 -- g| 23.3 t| Future Developments g| 664 -- g| 24 t| Marker-Assisted Selection and Introgression / r| J.C. Whittaker g| 673 -- g| 24.2 t| Marker-Assisted Selection: Inbred Line Crosses g| 674 -- g| 24.3 t| Marker-Assisted Selection: Outbred Populations g| 681 -- g| 24.4 t| Marker-Assisted Introgression g| 686 -- g| Part 6 t| Applications g| 695 -- g| 25 t| Ethics in the Use of Statistics in Genetics / r| D. Beyleveld g| 697 -- g| 25.2 t| What is Ethics? g| 698 -- g| 25.3 t| Normative Moral Theories and Institutionalized Consensus g| 700 -- g| 25.4 t| Uses of Statistics g| 709 -- g| 26 t| Forensics / r| B.S. Weir g| 721 -- g| 26.2 t| Principles of Interpretation g| 722 -- g| 26.3 t| Profile Probabilities g| 724 -- g| 26.4 t| Mixtures g| 730 -- g| 26.5 t| Sampling Issues g| 733 -- g| 26.6 t| Other Forensic Issues g| 735 -- g| 27 t| Pharmacogenetics / r| N.J. Schork, D. Fallin, H.K. Tiwari, M.A. Schork g| 741 -- g| 27.1 t| Introduction: The Scope of Pharmacogenetics g| 742 -- g| 27.2 t| General Issues in the Pharmacogenetic Analysis of Clinical Trials g| 743 -- g| 27.3 t| Phenotypic and Outcome Assessment via Mixture Distribution Analysis g| 746 -- g| 27.4 t| Optimal Genotyping Protocols via Extreme Sampling g| 749 -- g| 27.5 t| Multilocus and Haplotype Analysis g| 752 -- g| 27.6 t| Assessing Sample Homogeneity g| 755 -- g| 27.7 t| Sequential Pharmacogenetic Designs g| 757 -- g| 28 t| Statistical Basis of Risk Calculations / r| R. Chakraborty g| 765 -- g| 28.2 t| Concept of Risk in the Formulation of Bayesian Inference g| 766 -- g| 28.3 t| Various Stages of Risk Estimation g| 767 -- g| 28.4 t| Major Advances in Estimating the Conditional Probability g| 768 -- g| 28.5 t| Use of Genetic Data in Other Types of Risk Estimation g| 772 -- g| 29 t| Conservation Genetics / r| M.A. Beaumont g| 779 --
    505
    8
    0
    g| 29.2 t| Estimating Effective Population Size g| 780 -- g| 29.3 t| Hybridization g| 798 -- g| 30 t| Genetic History of the Human Species / r| J.H. Relethford g| 813 -- g| 30.2 t| Models of Modern Human Origins g| 814 -- g| 30.3 t| Gene Trees g| 818 -- g| 30.4 t| African Genetic Diversity g| 824 -- g| 30.5 t| Genetic Distances Between Living Human Populations g| 828 -- g| 30.6 t| Genetic Demography of the Human Species g| 832.
    590
      
      
    a| HEALTH SCIENCES: Purchased with support from the Ralph Erskine Conrad Memorial Fund.
    596
      
      
    a| 5 19
    650
      
    0
    a| Genetics x| Statistical methods v| Handbooks, manuals, etc.
    650
    1
    2
    a| Genetics x| statistics & numerical data v| Handbooks.
    700
    1
      
    a| Balding, D. J.
    700
    1
      
    a| Bishop, M. J. q| (Martin J.)
    700
    1
      
    a| Cannings, C. q| (Christopher), d| 1942-
    999
      
      
    a| QH438.4 .S73 H36 2001 w| LC i| X004475662 l| STACKS m| SCI-ENG t| BOOK
    999
      
      
    a| QH438.4 .S73 H36 2001 w| HS-LC i| 3470368418 l| BKSTACKS m| HEALTHSCI t| BOOK

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