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Genomic Regulatory Systems: Development and Evolution

Eric H. Davidson
Format
Book
Published
San Diego : Academic Press, c2001.
Language
English
ISBN
0122053516
Contents
  • 1. Regulatory Hardwiring: A Brief Overview of the Genomic Control Apparatus and its Causal Role in Development and Evolution
  • Regulatory Apparatus Encoded in the DNA
  • Genes and Gene Regulatory Components of Animal Genomes 2
  • Overview of Regulatory Architecture 7
  • Gene Regulatory Functions in Development 11
  • Regulatory Demands of Development 11
  • Pattern Formation 13
  • Terminal Differentiation 16
  • Genomic Regulatory Sequence and the Evolution of Morphological Features 18
  • Regulatory Evolution, and Evolution in General 19
  • Bilaterian Phylogeny 20
  • 2. Inside the cis-Regulatory Module: Control Logic, and How Regulatory Environment is Transduced into Spatial Patterns of Gene Expression
  • Operating Principles for cis-Regulatory Systems that Mediate Developmental Specification Events 26
  • Spatial Repression in cis-Regulatory specification 28
  • Two Very Different Examples of Similar Import 28
  • cis-Regulatory Design for Autonomous Modular Function 35
  • Generality of Repression 41
  • Downstream of Specification 44
  • At the Beginning of Embryogenesis 46
  • Polyfunctional Downstream Modules 48
  • "Power" of the cis-Regulatory Module 49
  • Diverse cis-Regulatory Outputs from a Simple Input 50
  • Direct Integration of Noncoincident Spatial Inputs 52
  • A cis-Regulatory Logic Device 54
  • 3. Regulation of Direct Cell-Type Specification in Early Development
  • Basic Package for Bilaterian Embryogenesis: Type 1 Specification Processes 64
  • Regulatory Mechanism in Territorial Specification of the Sea Urchin Embryo 66
  • Definitive Territories of the Embryo 66
  • Early Transcriptional Activation of Cell Type-specific Genes 71
  • Initial Regulatory Processes 74
  • Multiple Inputs for Endomesoderm Specification 75
  • Regulatory Mechanisms Controlling Specification in Ascidian Embryos 81
  • Territorial Specification 81
  • Mechanisms and Pathways in Mesoderm Specification 85
  • Caenorhabditis elegans: The Genomic Apparatus for Endoderm Specification 92
  • Endoderm Specification 93
  • Network of Zygotic cis-Regulatory Interactions Required for Endoderm Specification 96
  • Short Summary: Quality of Type 1 Regulatory Networks 101
  • 4. Secret of the Bilaterians: Abstract Regulatory Design in Building Adult Body Parts
  • Evolutionary Significance of "Pattern Formation" 103
  • First Step: Transcriptional Definition of the Domain of the Body Part 105
  • Morphological Pieces and Regulatory Subpatterns 110
  • Heart Parts 110
  • Forelimb and Hindlimb Buds 111
  • Transcriptional Domains in the Gut Endoderm 115
  • Patterns in the Developing Hindbrain 117
  • Appendage Parts and Transcriptional Patterns in Drosophila Imaginal Discs 121
  • Glimpses of How It Works 122
  • Transcriptional Domains and the Pattern Program for the Drosophila Wing Disc: Modularity and cis-Regulatory Inputs 123
  • Patterning the Heart Progenitor Field in Drosophila 129
  • Encoding Hindbrain Regulatory Patterns 131
  • Role of Signaling 140
  • Last Routines: Calling in Differentiation Programs 146
  • Specification of Peripheral Nervous System Elements in the Drosophila Wing 147
  • Installation of Cell Type-specific Differentiation Programs in the Pituitary 152
  • 5. Changes that Make New Forms: Gene Regulatory Systems and the Evolution of Body Plans
  • Some Examples: Evolutionary Cooption of Genes to New Pattern Formation Functions 158
  • hox Gene Functions and Cooptions of the hox Cluster Patterning System 164
  • A Specific Case of A/P Patterning: How a hox Gene Does Its Job 166
  • Evolutionary Changes in hox Gene Expression in the Arthropods 167
  • Off the A/P Axis 174
  • Colinear Expression of hox Genes in the Somatocoels of Sea Urchin Larvae 178
  • Small Changes 183
  • Evolutionary Origins of Body Parts 188
  • Polarity in Body Part Evolution 188
  • Case of pax6 and Some Other Amazing Examples 191
  • Concluding Comment:7 Conceiving Evolution as a Process of Change in Regulatory Gene Networks 201.
Description
xii, 261 p. : col. ill. ; 25 cm.
Notes
Includes bibliographical references (p. 203-244) and index.
Technical Details
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    g| 1. t| Regulatory Hardwiring: A Brief Overview of the Genomic Control Apparatus and its Causal Role in Development and Evolution -- t| Regulatory Apparatus Encoded in the DNA -- t| Genes and Gene Regulatory Components of Animal Genomes g| 2 -- t| Overview of Regulatory Architecture g| 7 -- t| Gene Regulatory Functions in Development g| 11 -- t| Regulatory Demands of Development g| 11 -- t| Pattern Formation g| 13 -- t| Terminal Differentiation g| 16 -- t| Genomic Regulatory Sequence and the Evolution of Morphological Features g| 18 -- t| Regulatory Evolution, and Evolution in General g| 19 -- t| Bilaterian Phylogeny g| 20 -- g| 2. t| Inside the cis-Regulatory Module: Control Logic, and How Regulatory Environment is Transduced into Spatial Patterns of Gene Expression -- t| Operating Principles for cis-Regulatory Systems that Mediate Developmental Specification Events g| 26 -- t| Spatial Repression in cis-Regulatory specification g| 28 -- t| Two Very Different Examples of Similar Import g| 28 -- t| cis-Regulatory Design for Autonomous Modular Function g| 35 -- t| Generality of Repression g| 41 -- t| Downstream of Specification g| 44 -- t| At the Beginning of Embryogenesis g| 46 -- t| Polyfunctional Downstream Modules g| 48 -- t| "Power" of the cis-Regulatory Module g| 49 -- t| Diverse cis-Regulatory Outputs from a Simple Input g| 50 -- t| Direct Integration of Noncoincident Spatial Inputs g| 52 -- t| A cis-Regulatory Logic Device g| 54 -- g| 3. t| Regulation of Direct Cell-Type Specification in Early Development -- t| Basic Package for Bilaterian Embryogenesis: Type 1 Specification Processes g| 64 -- t| Regulatory Mechanism in Territorial Specification of the Sea Urchin Embryo g| 66 -- t| Definitive Territories of the Embryo g| 66 -- t| Early Transcriptional Activation of Cell Type-specific Genes g| 71 -- t| Initial Regulatory Processes g| 74 -- t| Multiple Inputs for Endomesoderm Specification g| 75 -- t| Regulatory Mechanisms Controlling Specification in Ascidian Embryos g| 81 -- t| Territorial Specification g| 81 -- t| Mechanisms and Pathways in Mesoderm Specification g| 85 -- t| Caenorhabditis elegans: The Genomic Apparatus for Endoderm Specification g| 92 -- t| Endoderm Specification g| 93 -- t| Network of Zygotic cis-Regulatory Interactions Required for Endoderm Specification g| 96 -- t| Short Summary: Quality of Type 1 Regulatory Networks g| 101 -- g| 4. t| Secret of the Bilaterians: Abstract Regulatory Design in Building Adult Body Parts -- t| Evolutionary Significance of "Pattern Formation" g| 103 -- t| First Step: Transcriptional Definition of the Domain of the Body Part g| 105 -- t| Morphological Pieces and Regulatory Subpatterns g| 110 -- t| Heart Parts g| 110 -- t| Forelimb and Hindlimb Buds g| 111 -- t| Transcriptional Domains in the Gut Endoderm g| 115 -- t| Patterns in the Developing Hindbrain g| 117 -- t| Appendage Parts and Transcriptional Patterns in Drosophila Imaginal Discs g| 121 -- t| Glimpses of How It Works g| 122 -- t| Transcriptional Domains and the Pattern Program for the Drosophila Wing Disc: Modularity and cis-Regulatory Inputs g| 123 -- t| Patterning the Heart Progenitor Field in Drosophila g| 129 -- t| Encoding Hindbrain Regulatory Patterns g| 131 -- t| Role of Signaling g| 140 -- t| Last Routines: Calling in Differentiation Programs g| 146 -- t| Specification of Peripheral Nervous System Elements in the Drosophila Wing g| 147 -- t| Installation of Cell Type-specific Differentiation Programs in the Pituitary g| 152 -- g| 5. t| Changes that Make New Forms: Gene Regulatory Systems and the Evolution of Body Plans -- t| Some Examples: Evolutionary Cooption of Genes to New Pattern Formation Functions g| 158 -- t| hox Gene Functions and Cooptions of the hox Cluster Patterning System g| 164 -- t| A Specific Case of A/P Patterning: How a hox Gene Does Its Job g| 166 -- t| Evolutionary Changes in hox Gene Expression in the Arthropods g| 167 -- t| Off the A/P Axis g| 174 -- t| Colinear Expression of hox Genes in the Somatocoels of Sea Urchin Larvae g| 178 -- t| Small Changes g| 183 -- t| Evolutionary Origins of Body Parts g| 188 -- t| Polarity in Body Part Evolution g| 188 -- t| Case of pax6 and Some Other Amazing Examples g| 191 -- t| Concluding Comment:7 Conceiving Evolution as a Process of Change in Regulatory Gene Networks g| 201.
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    a| QH453 .D384 2001 w| LC i| X004704902 l| BY-REQUEST m| IVY t| BOOK
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    a| QH453 .D384 2001 w| LC i| X004527936 k| LOST l| LOSTCLOSED m| SCI-ENG t| BOOK
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