Item Details

Host Factors in Defense Against Bacterial and Fungal Pneumonia

Bettina, Alexandra
Format
Thesis/Dissertation; Online
Author
Bettina, Alexandra
Advisor
Mehrad, Borna
Abstract
Pneumonia is a serious and life-threatening infection caused by a variety of microorganisms including bacteria and fungi. Antibiotic resistance among Gram-negative and Gram-positive bacteria is increasing and necessitates the discovery of alternative therapeutics. Fungal pneumonia is a life-threatening infection in immunocompromised hosts, and even with treatment, mortality associated with infection is high. I undertook two studies to examine the role of host factors in defense against bacterial and fungal pneumonia. I first assessed the role of macrophage colony stimulating factor (M-CSF) on mononuclear phagocytes during bacterial pneumonia. Second, I examined the ability of the gut microbiota to influence host defense against invasive pulmonary aspergillosis. My findings suggest that host factors are critical in defense against bacterial and fungal pneumonia.
Language
English
Date Received
20160714
Published
University of Virginia, Department of Microbiology, PHD (Doctor of Philosophy), 2016
Published Date
2016-07-19
Degree
PHD (Doctor of Philosophy)
Collection
Libra ETD Repository
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