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Textbook of Influenza [electronic resource]

Webster, Robert G; Monto, Arnold S; Braciale, Thomas J; Lamb, Robert A
EBook; Book; Online
Hoboken : Wiley, 2013.
2nd ed
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Virtual Library of Virginia EBL DDA purchased title
9781118636848, 1118636848
The Textbook of Influenza is a comprehensive resource covering all aspects of influenza, from the genetic and molecular biology of the virus through to clinical aspects of the disease and the latest drug developments and treatments. This new edition has been completely revised and reflects the integration of disciplines concerning the emergence, evolution, pathogenesis and control of influenza viruses in the field of human and veterinary public health. Textbook of Influenza examines the lessons learnt from the latest pandemic and provides the current state of knowledge f.
  • Cover; Copyright page; Contents; List of Contributors; Foreword to the Second Edition; Preface to the second edition; Acknowledgments; PART 1: Influenza: Perspective; 1: Human influenza: One health, one world; Introduction; Global impact of influenza; Influenza in a crowded, connected, and converging world; Increasingly crowded; Increasingly connected; Convergence: poultry, pigs, people, and pandemics; Global interconnectedness requires global coordination and response; Global challenges for surveillance; Global regulations for detection and control; Global network for surveillance.
  • New opportunities in a changing worldNew tools for global detection and surveillance; Instant and converging information; Conclusions; Acknowledgments; References; 2: Influenza pandemics: History and lessons learned; Introduction; Past and recent influenza pandemics; The 1889 and 1918 pandemics; The 1957 and 1968 pandemics; Events in 1976 and 1977; The threat of an A (H5N1) pandemic; Response to the H5N1 threat; The 2009 H1N1 influenza pandemic; Lessons learned from past influenza pandemics; Zoonotic origins and unpredictability of pandemics; Surveillance in swine was inadequate.
  • Antigenic and structural similarities are not predictors of severityAn influenza pandemic can arise anywhere in the world; Pandemic influenza can emerge in any season; Initial retention of avian receptor binding characteristics in pandemic influenza viruses; Vaccines to pandemic influenza viruses are not available during the first wave of infection; Antivirals are the first line of defense; Conclusions; Acknowledgments; References; PART 2: Structure and replication; 3: Structure, disassembly, assembly, and budding of influenza viruses; Introduction; Structure and virus morphology; Structure.
  • Virus morphologyDisassembly; Fusion process; Release of viral RNP; Transport and assembly; Budding; Role of viral proteins; Role of the eight RNP segments; Role of host components; Bud initiation; Bud elongation and closure; Conclusions; Acknowledgments; References; 4: The virus genome and its replication; The segmented RNA virus genome of influenza A and B viruses; Viral mRNA synthesis (transcription) and viral RNA replication; Regulation of viral RNA synthesis in infected cells; The role of host factors in viral RNA synthesis; Splicing and nuclear export of viral mRNAs.
  • Nuclear export of viral RNPsReferences; 5: Influenza glycoproteins: Hemagglutinin and neuraminidase; HA and NA structures, functions, antigenicity and classification: An overview; Functions of hemagglutinin; Receptor binding; Receptor binding summary; Hemagglutinin-mediated membrane fusion; Membrane fusion summary; Neuraminidase; Inhibitors of HA and NA functions and potential antiviral drugs; Receptor binding; Membrane fusion; Anti-NA drugs; Prospects for additional targets for inhibition; Antigenicity of HA and NA; Structures of complexes formed by HA and NA with antibodies.
1 online resource (522 pages)
Infectivity neutralization.
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