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Secretory Vesicles Deliver Cdc42p to Sites of Polarized Growth in S. Cerevisiae

Kozminski, Keith; Dighe, Shubha
Format
Article
Author
Kozminski, Keith
Dighe, Shubha
Abstract
he activation and localization of the Rho-family GTPase Cdc42p at one pole of a cell is necessary for maintaining an axis of polarized growth in many animal and fungal cells. How the asymmetric distribution of this key regulator of polarized morphogenesis is maintained is not fully understood, though divergent models have emerged from a congruence of multiple studies, including one that posits a role for polarized secretion. Here we show with S. cerevisiae that Cdc42p associates with secretory vesicles in vivo.
Language
English
Date Received
2014-06-20
Published
Public Library of Science, 2014
Published Date
2014
Sponsoring Agency
National Science Foundation, University of Virginia
Rights
All rights reserved (no additional license for public reuse)
Notes
This work has passed a peer-review process.
Collection
Libra Open Repository
Related Resources
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0099494

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