Item Details

High-Dimensional Ordinary Differential Equation Models for Connectivity Studies

Wu, Jingwei
Format
Thesis/Dissertation; Online
Author
Wu, Jingwei
Advisor
Zhang, Tingting
Abstract
We introduce a dynamic directional model (DDM) for studying brain effective connectivity based on intracranial electrocorticographic (ECoG) time series. The DDM consists of two parts: a set of differential equations describing neuronal activity of brain components (state equations), and observation equations linking the underlying neuronal states to observed data. The combined high temporal and spatial resolution of ECoG data result in a much simpler DDM, allowing investigation of complex connections between many regions. To identify functionally-segregated subnetworks, a form of biologically economical brain networks, we propose the Potts model for the DDM parameters. The neuronal states of brain components are represented by cubic spline bases and the parameters are estimated by minimizing a log-likelihood criterion that combines the state and observation equations. The Potts model is converted to the Potts penalty in the penalized regression approach to achieve sparsity in parameter estimation, for which a fast iterative algorithm is developed. An L1 penalty is also considered for comparison. The methods are applied to an auditory ECoG data set and extensive simulation studies.
Language
English
Date Received
20150408
Published
University of Virginia, Department of Statistics, PHD (Doctor of Philosophy), 2015
Published Date
2015-04-07
Degree
PHD (Doctor of Philosophy)
Collection
Libra ETD Repository
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