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New Approaches for Analyzing Biological Sequences

Zhang, Tongtong
Format
Thesis/Dissertation; Online
Author
Zhang, Tongtong
Advisor
Pearson, William
Robins, Gabriel
Abstract
We developed new approaches for analyzing biological sequences, a fundamental task in modern molecular biology. First, we formulated and analyzed heuristics for detecting new memebers of gene famiies using judicious primer selection in polymerase chain reactions. Secondly, we focused on reliability aspects of phylogenetic tree reconstruction and developed methods that detect trees with near-optimal cost yet diverse topologies. Finally, we investigated general approaches for assessing the topographical similarity between phylogenetic solution spaces induced by various optimality criteria.
Published
University of Virginia, Department of Computer Science, PHD (Doctor of Philosophy), 1999
Published Date
1999-01-29
Degree
PHD (Doctor of Philosophy)
Collection
Libra ETD Repository
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