Item Details

Di-and Mono- Phenyl Amine Based Sodium Channel Blockers for the Treatment of Pain

Hudgens, Debjani Patangia
Format
Thesis/Dissertation; Online
Author
Hudgens, Debjani Patangia
Advisor
Brown, Milton
Patel, Manoj
Williams, Mark
Abstract
Ion channels play a major role in the cellular signaling and control processes required within living systems. The voltage gated sodium channel (VGSC) belongs to this superfamily of ion channels and is known to have a critical function in electrically excitable cells, such as those found in neuronal, muscular and cardiac tissue. Ectopic firing of action potentials within neuronal systems can result in chronic pain syndromes, such as neuropathic pain. Therefore, VGSCs are central to the development of pain therapeutics. Tricyclic antidepressants (TCAs), such as amitripyline, serve as the best treatment of neuropathic pain syndromes, to date and are thought to function by potently blocking sodium channel current. Although TCAs have wide therapeutic use, they do suffer from some adverse side effects which have led to patient withdrawal. We have therefore chosen to develop novel compounds from an amitriptyline scaffold, in order to obtain a more well tolerated and potent therapeutic. From our investigations, we have been able to identify two potent classes of amitriptyline analogues, which are diand monophenyl amine. We have also determined that the tricyclic moiety is unnecessary for effective inhibition of both channel binding and sodium currents of hNa v 1.2. Additionally, modification to the amine functionality has been found to be detrimental to block. Thus far, our most potent compound containing a monophenyl amine structure provides 94.6 0.000000unctional block of sodium channels at 10 μM, which is a three-fold increase in current block in comparison to amitriptyline. Further evaluation of this analogue in animal models of inflammatory pain has shown promising results. Note: Abstract extracted from PDF text
Language
English
Date Received
20140123
Published
University of Virginia, Department of Chemistry, PHD (Doctor of Philosophy), 2007
Published Date
2007-01-01
Degree
PHD (Doctor of Philosophy)
Collection
Libra ETD Repository
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