Item Details

A Device for Delivering a Highly Localized Hyperthermia Treatment to Deep Seated Brain Tumors

Molloy, Janelle Arlene
Format
Thesis/Dissertation; Online
Author
Molloy, Janelle Arlene
Advisor
Sobottka, Stanley
Gillies, George
Ritter, Rogers C
Abstract
A device is being developed for producing a well localized hyperthermia treatment in deep-seated brain tumors. Heat deposition will be localized by preferential power deposition in a 3mm diameter metallic sphere. The sphere will be inserted through the brain into the tumor through a minimum damage path with the use of three dimensional remote magnetic manipulation. The asymmetric tumor will then be treated by rastering the sphere in three dimensions throughout the diseased volume while maintaining geometric sensitivity to tumor boundaries. A prototype of a magnetic manipulation system has been built which is capable of producing motion of a 3 mm diameter, 3 mm long NdFeB permanent magnet probe through a brain-like ''phantom". Forces are produced by a 2 k W electromagnet possessing a "neck-loop" design. Directionality of the force is provided through mechanical reorientation of the coil and is able to produce motion of the probe in two dimensions. The rheological properties of brain tissue were measured in a series of tests performed on in vitro dog brains. A transparent "phantom" gel was fabricated to simulate the mechanical properties of brain tissue while allowing visualization of motion of a probe undergoing manipulation with the magnet system already described. Note: Abstract extracted from PDF file via OCR.
Language
English
Date Received
20170928
Published
University of Virginia, Department of Physics , MS (Master of Science), 1988
Published Date
1988
Degree
MS (Master of Science)
Collection
Libra ETD Repository
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