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Development of H8BINOL-Amine Ligands and Their Application in Asymmetric Catalysis

DeBerardinis, Albert M
Format
Thesis/Dissertation; Online
Author
DeBerardinis, Albert M
Advisor
Venton, Jill
Harman, Dean
Abstract
Asymmetric catalysis has grown immensely over the past several decades. This was highlighted by the awarding of the Nobel Prize in Chemistry to Professors Sharpless, Noyori, and Knowles in 2001. As outlined by the Nobel Committee, the pioneering research efforts of these scientists demonstrated the exceedingly high potential of the synthetic methodology. These discoveries have had a vast impact on academic and industrial pursuits for the catalyzed chemical synthesis of chiral compounds. Pu lab research in the field of asymmetric catalysis has concentrated on the development of practically useful synthetic methodologies for the preparation of chiral compounds. This approach has centered on utilizing functionally tolerant organozincs and catalytic systems based on optically pure l,1' - bi - 2,2' - naphthol (BINOL) and derivatives of BINOL, such as BINOL - Amines (shown below). Note: Abstract extracted from PDF file via OCR
Language
English
Published
University of Virginia, Department of Chemistry, PHD (Doctor of Philosophy), 2011
Published Date
2011-01-01
Degree
PHD (Doctor of Philosophy)
Collection
Libra ETD Repository
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